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Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway

Clioquinol is an anti-microbial drug, and it was recently found to induce cancer cell death. In the present study, clioquinol was found to trigger autophagy by inducing LC3 lipidation and autophagosome formation which was abolished by an autophagy inhibitor 3-methyladenine. Further study showed clio...

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Detalles Bibliográficos
Autores principales:	Cao, Biyin, Li, Jie, Zhou, Xiumin, Juan, Jiaxiang, Han, Kunkun, Zhang, Zubin, Kong, Yan, Wang, Jianrong, Mao, Xinliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102920/ https://www.ncbi.nlm.nih.gov/pubmed/25034786 http://dx.doi.org/10.1038/srep05749

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