Cargando…

Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway

Clioquinol is an anti-microbial drug, and it was recently found to induce cancer cell death. In the present study, clioquinol was found to trigger autophagy by inducing LC3 lipidation and autophagosome formation which was abolished by an autophagy inhibitor 3-methyladenine. Further study showed clio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Biyin, Li, Jie, Zhou, Xiumin, Juan, Jiaxiang, Han, Kunkun, Zhang, Zubin, Kong, Yan, Wang, Jianrong, Mao, Xinliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102920/ https://www.ncbi.nlm.nih.gov/pubmed/25034786 http://dx.doi.org/10.1038/srep05749

Ejemplares similares

SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway
por: Han, Kunkun, et al.
Publicado: (2015)

Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway
por: Lu, Qin, et al.
Publicado: (2018)

An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway
por: Xu, Xin, et al.
Publicado: (2016)

Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization
por: Han, Kunkun, et al.
Publicado: (2014)

Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway
por: Shi, Liangqin, et al.
Publicado: (2020)

Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
por: Wang, Siyu, et al.
Publicado: (2017)

Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
por: Sun, Tong, et al.
Publicado: (2021)

Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia
por: Zhuang, Haixia, et al.
Publicado: (2022)

A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma
por: Zhu, Jingyu, et al.
Publicado: (2014)

Correction: A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma
por: Zhu, Jingyu, et al.
Publicado: (2019)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
por: Moon, Yunwon, et al.
Publicado: (2022)

Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha
por: Zeng, Yuanying, et al.
Publicado: (2017)

MicroRNA‐100 Enhances Autophagy and Suppresses Migration and Invasion of Renal Cell Carcinoma Cells via Disruption of NOX4‐Dependent mTOR Pathway
por: Liu, Xiumin, et al.
Publicado: (2020)

NQO1 protects against clioquinol toxicity
por: Chhetri, Jamuna, et al.
Publicado: (2022)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Radiosensitization of clioquinol and zinc in human cancer cell lines
por: Lu, Shan, et al.
Publicado: (2018)

Antimicrobial activity of clioquinol and nitroxoline: a scoping review
por: Wykowski, Rachel, et al.
Publicado: (2022)

Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in Vivo
por: Ke, Yuan, et al.
Publicado: (2020)

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy
por: Ganesan, Raja, et al.
Publicado: (2017)

Protective Role of mTOR in Liver Ischemia/Reperfusion Injury: Involvement of Inflammation and Autophagy
por: Zhang, Tao, et al.
Publicado: (2019)

A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway
por: Zhang, Zubin, et al.
Publicado: (2016)

Biological Aspects of mTOR in Leukemia
por: Mirabilii, Simone, et al.
Publicado: (2018)

Correction: A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway
por: Zhang, Zubin, et al.
Publicado: (2016)

Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway
por: Mao, Hongwu, et al.
Publicado: (2016)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

Development of a copper-clioquinol formulation suitable for intravenous use
por: Wehbe, Moe, et al.
Publicado: (2017)

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein
por: Lin, Gaoping, et al.
Publicado: (2021)

EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis
por: Xu, Hongmei, et al.
Publicado: (2019)

Arsenic trioxide promoting ETosis in acute promyelocytic leukemia through mTOR-regulated autophagy
por: Li, Tao, et al.
Publicado: (2018)

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf
por: Xu, Yujia, et al.
Publicado: (2020)

Targeting mTOR in Acute Lymphoblastic Leukemia
por: Simioni, Carolina, et al.
Publicado: (2019)

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma
por: Xie, Xiaoqi, et al.
Publicado: (2013)

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline
por: Lin, Shao Jian, et al.
Publicado: (2015)

Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway
por: Yang, Yang, et al.
Publicado: (2020)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

mTOR's role in ageing: protein synthesis or autophagy?
por: Hands, Sarah L., et al.
Publicado: (2009)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

The effects of clioquinol in morphogenesis, cell membrane and ion homeostasis in Candida albicans
por: You, Zimeng, et al.
Publicado: (2020)

Intra-articular injection of clioquinol ameliorates osteoarthritis in a rabbit model
por: Wu, Xiaoqing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lkmgprj725ic266mtlbq5ki9mh