Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma

BACKGROUND: The prognostic significance of BRAF and NRAS mutations in metastatic melanoma patients remains uncertain, with several studies reporting conflicting results, often biased by the inclusion of patients treated with BRAF and MEK (MAPK) inhibitors. We therefore interrogated a historical coho...

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Detalles Bibliográficos
Autores principales: Carlino, M S, Haydu, L E, Kakavand, H, Menzies, A M, Hamilton, A L, Yu, B, Ng, C C, Cooper, W A, Thompson, J F, Kefford, R F, O'Toole, S A, Scolyer, R A, Long, G V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102942/
https://www.ncbi.nlm.nih.gov/pubmed/24918823
http://dx.doi.org/10.1038/bjc.2014.287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102942/
https://www.ncbi.nlm.nih.gov/pubmed/24918823
http://dx.doi.org/10.1038/bjc.2014.287

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