Silicon-Containing GABA Derivatives, Silagaba Compounds, as Orally Effective Agents for Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects

[Image: see text] Neuropathic pain is a chronic condition resulting from neuronal damage. Pregabalin, the (S)-isomer of 3-isobutyl-γ-aminobutyric acid (GABA), is widely used to treat neuropathic pain, despite the occurrence of central nervous system (CNS)-related side effects such as dizziness and s...

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Detalles Bibliográficos
Autores principales: Fukasawa, Hiroshi, Muratake, Hideaki, Ito, Ai, Suzuki, Hideyuki, Amano, Yohei, Nagae, Marina, Sugiyama, Kiyoshi, Shudo, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102965/
https://www.ncbi.nlm.nih.gov/pubmed/24738473
http://dx.doi.org/10.1021/cn500053d

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