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Excessive production and extreme editing of human metapneumovirus defective interfering RNA is associated with type I IFN induction

Type I IFN production is one of the hallmarks of host innate immune responses upon virus infection. Whilst most respiratory viruses carry IFN antagonists, reports on human metapneumovirus (HMPV) have been conflicting. Using deep sequencing, we have demonstrated that HMPV particles accumulate excessi...

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Detalles Bibliográficos
Autores principales:	van den Hoogen, Bernadette G., van Boheemen, Sander, de Rijck, Jonneke, van Nieuwkoop, Stefan, Smith, Derek J., Laksono, Brigitta, Gultyaev, Alexander, Osterhaus, Albert D. M. E., Fouchier, Ron A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for General Microbiology 2014
Materias:	Animal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103063/ https://www.ncbi.nlm.nih.gov/pubmed/24760760 http://dx.doi.org/10.1099/vir.0.066100-0

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