FAN1 Activity on Asymmetric Repair Intermediates Is Mediated by an Atypical Monomeric Virus-type Replication-Repair Nuclease Domain

FAN1 is a structure-selective DNA repair nuclease with 5′ flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair nuclease (“VRR-Nuc”) “module” that commonly occurs as a standalone domain in many bacteri...

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Detalles Bibliográficos
Autores principales: Pennell, Simon, Déclais, Anne-Cécile, Li, Jiejin, Haire, Lesley F., Berg, Wioletta, Saldanha, José W., Taylor, Ian A., Rouse, John, Lilley, David M.J., Smerdon, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103454/
https://www.ncbi.nlm.nih.gov/pubmed/24981866
http://dx.doi.org/10.1016/j.celrep.2014.06.001

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