MicroRNA-9 Modulates Hes1 Ultradian Oscillations by Forming a Double-Negative Feedback Loop

Short-period (ultradian) oscillations of Hes1, a Notch signaling effector, are essential for maintaining neural progenitors in a proliferative state, while constitutive downregulation of Hes1 leads to neuronal differentiation. Hes1 oscillations are driven by autorepression, coupled with high instabi...

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Detalles Bibliográficos
Autores principales: Bonev, Boyan, Stanley, Peter, Papalopulu, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103481/
https://www.ncbi.nlm.nih.gov/pubmed/22840391
http://dx.doi.org/10.1016/j.celrep.2012.05.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103481/
https://www.ncbi.nlm.nih.gov/pubmed/22840391
http://dx.doi.org/10.1016/j.celrep.2012.05.017

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