Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase

Pantothenol is a provitamin of pantothenic acid (vitamin B(5)) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes...

Descripción completa

Detalles Bibliográficos
Autores principales: Chohnan, Shigeru, Murase, Misa, Kurikawa, Kota, Higashi, Kodai, Ogata, Yuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Microbial Ecology/The Japanese Society of Soil Microbiology 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103530/
https://www.ncbi.nlm.nih.gov/pubmed/24759689
http://dx.doi.org/10.1264/jsme2.ME13178
_version_ 1782327163189460992
author Chohnan, Shigeru
Murase, Misa
Kurikawa, Kota
Higashi, Kodai
Ogata, Yuta
author_facet Chohnan, Shigeru
Murase, Misa
Kurikawa, Kota
Higashi, Kodai
Ogata, Yuta
author_sort Chohnan, Shigeru
collection PubMed
description Pantothenol is a provitamin of pantothenic acid (vitamin B(5)) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens.
format Online
Article
Text
id pubmed-4103530
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Japanese Society of Microbial Ecology/The Japanese Society of Soil Microbiology
record_format MEDLINE/PubMed
spelling pubmed-41035302014-07-24 Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase Chohnan, Shigeru Murase, Misa Kurikawa, Kota Higashi, Kodai Ogata, Yuta Microbes Environ Short Communication Pantothenol is a provitamin of pantothenic acid (vitamin B(5)) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens. Japanese Society of Microbial Ecology/The Japanese Society of Soil Microbiology 2014-06 2014-04-22 /pmc/articles/PMC4103530/ /pubmed/24759689 http://dx.doi.org/10.1264/jsme2.ME13178 Text en Copyright 2014 by Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Chohnan, Shigeru
Murase, Misa
Kurikawa, Kota
Higashi, Kodai
Ogata, Yuta
Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase
title Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase
title_full Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase
title_fullStr Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase
title_full_unstemmed Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase
title_short Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase
title_sort antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type ii pantothenate kinase
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103530/
https://www.ncbi.nlm.nih.gov/pubmed/24759689
http://dx.doi.org/10.1264/jsme2.ME13178
work_keys_str_mv AT chohnanshigeru antimicrobialactivityofpantothenolagainststaphylococcipossessingaprokaryotictypeiipantothenatekinase
AT murasemisa antimicrobialactivityofpantothenolagainststaphylococcipossessingaprokaryotictypeiipantothenatekinase
AT kurikawakota antimicrobialactivityofpantothenolagainststaphylococcipossessingaprokaryotictypeiipantothenatekinase
AT higashikodai antimicrobialactivityofpantothenolagainststaphylococcipossessingaprokaryotictypeiipantothenatekinase
AT ogatayuta antimicrobialactivityofpantothenolagainststaphylococcipossessingaprokaryotictypeiipantothenatekinase

Ejemplares similares