Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

The genetic contribution to the variation in human lifespan is ∼25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent...

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Autores principales: Deelen, Joris, Beekman, Marian, Uh, Hae-Won, Broer, Linda, Ayers, Kristin L., Tan, Qihua, Kamatani, Yoichiro, Bennet, Anna M., Tamm, Riin, Trompet, Stella, Guðbjartsson, Daníel F., Flachsbart, Friederike, Rose, Giuseppina, Viktorin, Alexander, Fischer, Krista, Nygaard, Marianne, Cordell, Heather J., Crocco, Paolina, van den Akker, Erik B., Böhringer, Stefan, Helmer, Quinta, Nelson, Christopher P., Saunders, Gary I., Alver, Maris, Andersen-Ranberg, Karen, Breen, Marie E., van der Breggen, Ruud, Caliebe, Amke, Capri, Miriam, Cevenini, Elisa, Collerton, Joanna C., Dato, Serena, Davies, Karen, Ford, Ian, Gampe, Jutta, Garagnani, Paolo, de Geus, Eco J.C., Harrow, Jennifer, van Heemst, Diana, Heijmans, Bastiaan T., Heinsen, Femke-Anouska, Hottenga, Jouke-Jan, Hofman, Albert, Jeune, Bernard, Jonsson, Palmi V., Lathrop, Mark, Lechner, Doris, Martin-Ruiz, Carmen, Mcnerlan, Susan E., Mihailov, Evelin, Montesanto, Alberto, Mooijaart, Simon P., Murphy, Anne, Nohr, Ellen A., Paternoster, Lavinia, Postmus, Iris, Rivadeneira, Fernando, Ross, Owen A., Salvioli, Stefano, Sattar, Naveed, Schreiber, Stefan, Stefánsson, Hreinn, Stott, David J., Tiemeier, Henning, Uitterlinden, André G., Westendorp, Rudi G.J., Willemsen, Gonneke, Samani, Nilesh J., Galan, Pilar, Sørensen, Thorkild I.A., Boomsma, Dorret I., Jukema, J. Wouter, Rea, Irene Maeve, Passarino, Giuseppe, de Craen, Anton J.M., Christensen, Kaare, Nebel, Almut, Stefánsson, Kári, Metspalu, Andres, Magnusson, Patrik, Blanché, Hélène, Christiansen, Lene, Kirkwood, Thomas B.L., van Duijn, Cornelia M., Franceschi, Claudio, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672/
https://www.ncbi.nlm.nih.gov/pubmed/24688116
http://dx.doi.org/10.1093/hmg/ddu139

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