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Dynamic and Multi-Pharmacophore Modeling for Designing Polo-Box Domain Inhibitors

The polo-like kinase 1 (Plk1) is a critical regulator of cell division that is overexpressed in many types of tumors. Thus, a strategy in the treatment of cancer has been to target the kinase activity (ATPase domain) or substrate-binding domain (Polo-box Domain, PBD) of Plk1. However, only few synth...

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Detalles Bibliográficos
Autores principales:	Sakkiah, Sugunadevi, Senese, Silvia, Yang, Qianfan, Lee, Keun Woo, Torres, Jorge Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103762/ https://www.ncbi.nlm.nih.gov/pubmed/25036740 http://dx.doi.org/10.1371/journal.pone.0101405

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