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The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies
BACKGROUND: The genetic polymorphisms of glutathione S-transferase (GSTs) have been suspected to be related to the development of lung cancer while the current results are conflicting, especially in the Chinese population. METHODS: Data on genetic polymorphisms of glutathione S-transferase Mu 1 (GST...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103841/ https://www.ncbi.nlm.nih.gov/pubmed/25036724 http://dx.doi.org/10.1371/journal.pone.0102372 |
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author | Liu, Kui Lin, Xialu Zhou, Qi Ma, Ting Han, Liyuan Mao, Guochuan Chen, Jian Yue, Xia Wang, Huiqin Zhang, Lu Jin, Guixiu Jiang, Jianmin Zhao, Jinshun Zou, Baobo |
author_facet | Liu, Kui Lin, Xialu Zhou, Qi Ma, Ting Han, Liyuan Mao, Guochuan Chen, Jian Yue, Xia Wang, Huiqin Zhang, Lu Jin, Guixiu Jiang, Jianmin Zhao, Jinshun Zou, Baobo |
author_sort | Liu, Kui |
collection | PubMed |
description | BACKGROUND: The genetic polymorphisms of glutathione S-transferase (GSTs) have been suspected to be related to the development of lung cancer while the current results are conflicting, especially in the Chinese population. METHODS: Data on genetic polymorphisms of glutathione S-transferase Mu 1 (GSTM1) from 68 studies, glutathione S-transferase theta 1 (GSTT1) from 17 studies and GSTM1-GSTT1 from 8 studies in the Chinese population were reanalyzed on their association with lung cancer risk. Odds ratios (OR) were pooled using forest plots. 9 subgroups were all or partly performed in the subgroup analyses. The Galbraith plot was used to identify the heterogeneous records. Potential publication biases were detected by Begg's and Egger's tests. RESULTS: 71 eligible studies were identified after screening of 1608 articles. The increased association between two vital GSTs genetic polymorphisms and lung cancer risk was detected by random-effects model based on a comparable heterogeneity. Subgroup analysis showed a significant relationship between squamous carcinoma (SC), adenocarcinoma (AC) or small cell lung carcinoma (SCLC) and GSTM1 null genotype, as well as SC or AC and GSTT1 null genotype. Additionally, smokers with GSTM1 null genotype had a higher lung cancer risk than non-smokers. Our cumulative meta-analysis demonstrated a stable and reliable result of the relationship between GSTM1 null genotype and lung cancer risk. After the possible heterogeneous articles were omitted, the adjusted risk of GSTs and lung cancer susceptibility increased (fixed-effects model: OR(GSTM1) = 1.23, 95% CI: 1.19 to 1.27, P<0.001; OR(GSTT1) = 1.18, 95% CI: 1.10 to 1.26, P<0.001; OR(GSTM1-GSTT1) = 1.33, 95% CI: 1.10 to 1.61, P = 0.004). CONCLUSIONS: An increased risk of lung cancer with GSTM1 and GSTT1 null genotype, especially with dual null genotype, was found in the Chinese population. In addition, special histopathological classification of lung cancers and a wide range of gene-environment and gene-gene interaction analysis should be taken into consideration in future studies. |
format | Online Article Text |
id | pubmed-4103841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41038412014-07-21 The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies Liu, Kui Lin, Xialu Zhou, Qi Ma, Ting Han, Liyuan Mao, Guochuan Chen, Jian Yue, Xia Wang, Huiqin Zhang, Lu Jin, Guixiu Jiang, Jianmin Zhao, Jinshun Zou, Baobo PLoS One Research Article BACKGROUND: The genetic polymorphisms of glutathione S-transferase (GSTs) have been suspected to be related to the development of lung cancer while the current results are conflicting, especially in the Chinese population. METHODS: Data on genetic polymorphisms of glutathione S-transferase Mu 1 (GSTM1) from 68 studies, glutathione S-transferase theta 1 (GSTT1) from 17 studies and GSTM1-GSTT1 from 8 studies in the Chinese population were reanalyzed on their association with lung cancer risk. Odds ratios (OR) were pooled using forest plots. 9 subgroups were all or partly performed in the subgroup analyses. The Galbraith plot was used to identify the heterogeneous records. Potential publication biases were detected by Begg's and Egger's tests. RESULTS: 71 eligible studies were identified after screening of 1608 articles. The increased association between two vital GSTs genetic polymorphisms and lung cancer risk was detected by random-effects model based on a comparable heterogeneity. Subgroup analysis showed a significant relationship between squamous carcinoma (SC), adenocarcinoma (AC) or small cell lung carcinoma (SCLC) and GSTM1 null genotype, as well as SC or AC and GSTT1 null genotype. Additionally, smokers with GSTM1 null genotype had a higher lung cancer risk than non-smokers. Our cumulative meta-analysis demonstrated a stable and reliable result of the relationship between GSTM1 null genotype and lung cancer risk. After the possible heterogeneous articles were omitted, the adjusted risk of GSTs and lung cancer susceptibility increased (fixed-effects model: OR(GSTM1) = 1.23, 95% CI: 1.19 to 1.27, P<0.001; OR(GSTT1) = 1.18, 95% CI: 1.10 to 1.26, P<0.001; OR(GSTM1-GSTT1) = 1.33, 95% CI: 1.10 to 1.61, P = 0.004). CONCLUSIONS: An increased risk of lung cancer with GSTM1 and GSTT1 null genotype, especially with dual null genotype, was found in the Chinese population. In addition, special histopathological classification of lung cancers and a wide range of gene-environment and gene-gene interaction analysis should be taken into consideration in future studies. Public Library of Science 2014-07-18 /pmc/articles/PMC4103841/ /pubmed/25036724 http://dx.doi.org/10.1371/journal.pone.0102372 Text en © 2014 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Liu, Kui Lin, Xialu Zhou, Qi Ma, Ting Han, Liyuan Mao, Guochuan Chen, Jian Yue, Xia Wang, Huiqin Zhang, Lu Jin, Guixiu Jiang, Jianmin Zhao, Jinshun Zou, Baobo The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies |
title | The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies |
title_full | The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies |
title_fullStr | The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies |
title_full_unstemmed | The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies |
title_short | The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies |
title_sort | associations between two vital gsts genetic polymorphisms and lung cancer risk in the chinese population: evidence from 71 studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103841/ https://www.ncbi.nlm.nih.gov/pubmed/25036724 http://dx.doi.org/10.1371/journal.pone.0102372 |
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