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Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus

Four avian metapneumovirus (AMPV) subgroups (A–D) have been reported previously based on genetic and antigenic differences. However, until now full length sequences of the only known isolates of European subgroup C and subgroup D viruses (duck and turkey origin, respectively) have been unavailable....

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Autores principales: Brown, Paul A., Lemaitre, Evelyne, Briand, François-Xavier, Courtillon, Céline, Guionie, Olivier, Allée, Chantal, Toquin, Didier, Bayon-Auboyer, Marie-Hélène, Jestin, Véronique, Eterradossi, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103871/
https://www.ncbi.nlm.nih.gov/pubmed/25036224
http://dx.doi.org/10.1371/journal.pone.0102740
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author Brown, Paul A.
Lemaitre, Evelyne
Briand, François-Xavier
Courtillon, Céline
Guionie, Olivier
Allée, Chantal
Toquin, Didier
Bayon-Auboyer, Marie-Hélène
Jestin, Véronique
Eterradossi, Nicolas
author_facet Brown, Paul A.
Lemaitre, Evelyne
Briand, François-Xavier
Courtillon, Céline
Guionie, Olivier
Allée, Chantal
Toquin, Didier
Bayon-Auboyer, Marie-Hélène
Jestin, Véronique
Eterradossi, Nicolas
author_sort Brown, Paul A.
collection PubMed
description Four avian metapneumovirus (AMPV) subgroups (A–D) have been reported previously based on genetic and antigenic differences. However, until now full length sequences of the only known isolates of European subgroup C and subgroup D viruses (duck and turkey origin, respectively) have been unavailable. These full length sequences were determined and compared with other full length AMPV and human metapneumoviruses (HMPV) sequences reported previously, using phylogenetics, comparisons of nucleic and amino acid sequences and study of codon usage bias. Results confirmed that subgroup C viruses were more closely related to HMPV than they were to the other AMPV subgroups in the study. This was consistent with previous findings using partial genome sequences. Closer relationships between AMPV-A, B and D were also evident throughout the majority of results. Three metapneumovirus “clusters” HMPV, AMPV-C and AMPV-A, B and D were further supported by codon bias and phylogenetics. The data presented here together with those of previous studies describing antigenic relationships also between AMPV-A, B and D and between AMPV-C and HMPV may call for a subclassification of metapneumoviruses similar to that used for avian paramyxoviruses, grouping AMPV-A, B and D as type I metapneumoviruses and AMPV-C and HMPV as type II.
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spelling pubmed-41038712014-07-21 Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus Brown, Paul A. Lemaitre, Evelyne Briand, François-Xavier Courtillon, Céline Guionie, Olivier Allée, Chantal Toquin, Didier Bayon-Auboyer, Marie-Hélène Jestin, Véronique Eterradossi, Nicolas PLoS One Research Article Four avian metapneumovirus (AMPV) subgroups (A–D) have been reported previously based on genetic and antigenic differences. However, until now full length sequences of the only known isolates of European subgroup C and subgroup D viruses (duck and turkey origin, respectively) have been unavailable. These full length sequences were determined and compared with other full length AMPV and human metapneumoviruses (HMPV) sequences reported previously, using phylogenetics, comparisons of nucleic and amino acid sequences and study of codon usage bias. Results confirmed that subgroup C viruses were more closely related to HMPV than they were to the other AMPV subgroups in the study. This was consistent with previous findings using partial genome sequences. Closer relationships between AMPV-A, B and D were also evident throughout the majority of results. Three metapneumovirus “clusters” HMPV, AMPV-C and AMPV-A, B and D were further supported by codon bias and phylogenetics. The data presented here together with those of previous studies describing antigenic relationships also between AMPV-A, B and D and between AMPV-C and HMPV may call for a subclassification of metapneumoviruses similar to that used for avian paramyxoviruses, grouping AMPV-A, B and D as type I metapneumoviruses and AMPV-C and HMPV as type II. Public Library of Science 2014-07-18 /pmc/articles/PMC4103871/ /pubmed/25036224 http://dx.doi.org/10.1371/journal.pone.0102740 Text en © 2014 Brown et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Brown, Paul A.
Lemaitre, Evelyne
Briand, François-Xavier
Courtillon, Céline
Guionie, Olivier
Allée, Chantal
Toquin, Didier
Bayon-Auboyer, Marie-Hélène
Jestin, Véronique
Eterradossi, Nicolas
Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus
title Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus
title_full Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus
title_fullStr Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus
title_full_unstemmed Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus
title_short Molecular Comparisons of Full Length Metapneumovirus (MPV) Genomes, Including Newly Determined French AMPV-C and –D Isolates, Further Supports Possible Subclassification within the MPV Genus
title_sort molecular comparisons of full length metapneumovirus (mpv) genomes, including newly determined french ampv-c and –d isolates, further supports possible subclassification within the mpv genus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103871/
https://www.ncbi.nlm.nih.gov/pubmed/25036224
http://dx.doi.org/10.1371/journal.pone.0102740
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