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WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

Mammalian cell homeostasis during starvation depends on initiation of autophagy by endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns(3)P) synthesis. Formation of double-membrane autophagosomes that engulf cytosolic components requires the LC3-conjugating Atg12–5-16L1 complex....

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Detalles Bibliográficos
Autores principales:	Dooley, Hannah C., Razi, Minoo, Polson, Hannah E.J., Girardin, Stephen E., Wilson, Michael I., Tooze, Sharon A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104028/ https://www.ncbi.nlm.nih.gov/pubmed/24954904 http://dx.doi.org/10.1016/j.molcel.2014.05.021

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