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Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric activator of α1-complexes that, like AMP, als...

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Detalles Bibliográficos
Autores principales:	Hunter, Roger W., Foretz, Marc, Bultot, Laurent, Fullerton, Morgan D., Deak, Maria, Ross, Fiona A., Hawley, Simon A., Shpiro, Natalia, Viollet, Benoit, Barron, Denis, Kemp, Bruce E., Steinberg, Gregory R., Hardie, D. Grahame, Sakamoto, Kei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104029/ https://www.ncbi.nlm.nih.gov/pubmed/25036776 http://dx.doi.org/10.1016/j.chembiol.2014.05.014

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