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Dual role of SIRT1 in UVB-induced skin tumorigenesis

The protein deacetylase SIRT1 regulates various pathways in metabolism, aging and cancer. However, the role of SIRT1 in skin cancer remains unclear. Here, using mice with targeted deletions of SIRT1 in their epidermis in both resistant B6 and sensitive SKH1 hairless backgrounds, we show that the rol...

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Detalles Bibliográficos
Autores principales:	Ming, Mei, Soltani, Keyoumars, Shea, Christopher R., Li, Xiaoling, He, Yu-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104262/ https://www.ncbi.nlm.nih.gov/pubmed/24441046 http://dx.doi.org/10.1038/onc.2013.583

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