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The Opisthorchis viverrini genome provides insights into life in the bile duct
Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel)...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104445/ https://www.ncbi.nlm.nih.gov/pubmed/25007141 http://dx.doi.org/10.1038/ncomms5378 |
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author | Young, Neil D. Nagarajan, Niranjan Lin, Suling Joyce Korhonen, Pasi K. Jex, Aaron R. Hall, Ross S. Safavi-Hemami, Helena Kaewkong, Worasak Bertrand, Denis Gao, Song Seet, Qihui Wongkham, Sopit Teh, Bin Tean Wongkham, Chaisiri Intapan, Pewpan Maleewong Maleewong, Wanchai Yang, Xinhua Hu, Min Wang, Zuo Hofmann, Andreas Sternberg, Paul W. Tan, Patrick Wang, Jun Gasser, Robin B. |
author_facet | Young, Neil D. Nagarajan, Niranjan Lin, Suling Joyce Korhonen, Pasi K. Jex, Aaron R. Hall, Ross S. Safavi-Hemami, Helena Kaewkong, Worasak Bertrand, Denis Gao, Song Seet, Qihui Wongkham, Sopit Teh, Bin Tean Wongkham, Chaisiri Intapan, Pewpan Maleewong Maleewong, Wanchai Yang, Xinhua Hu, Min Wang, Zuo Hofmann, Andreas Sternberg, Paul W. Tan, Patrick Wang, Jun Gasser, Robin B. |
author_sort | Young, Neil D. |
collection | PubMed |
description | Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions. |
format | Online Article Text |
id | pubmed-4104445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-41044452014-07-22 The Opisthorchis viverrini genome provides insights into life in the bile duct Young, Neil D. Nagarajan, Niranjan Lin, Suling Joyce Korhonen, Pasi K. Jex, Aaron R. Hall, Ross S. Safavi-Hemami, Helena Kaewkong, Worasak Bertrand, Denis Gao, Song Seet, Qihui Wongkham, Sopit Teh, Bin Tean Wongkham, Chaisiri Intapan, Pewpan Maleewong Maleewong, Wanchai Yang, Xinhua Hu, Min Wang, Zuo Hofmann, Andreas Sternberg, Paul W. Tan, Patrick Wang, Jun Gasser, Robin B. Nat Commun Article Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions. Nature Pub. Group 2014-07-09 /pmc/articles/PMC4104445/ /pubmed/25007141 http://dx.doi.org/10.1038/ncomms5378 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Article Young, Neil D. Nagarajan, Niranjan Lin, Suling Joyce Korhonen, Pasi K. Jex, Aaron R. Hall, Ross S. Safavi-Hemami, Helena Kaewkong, Worasak Bertrand, Denis Gao, Song Seet, Qihui Wongkham, Sopit Teh, Bin Tean Wongkham, Chaisiri Intapan, Pewpan Maleewong Maleewong, Wanchai Yang, Xinhua Hu, Min Wang, Zuo Hofmann, Andreas Sternberg, Paul W. Tan, Patrick Wang, Jun Gasser, Robin B. The Opisthorchis viverrini genome provides insights into life in the bile duct |
title | The Opisthorchis viverrini genome provides insights into life in the bile duct |
title_full | The Opisthorchis viverrini genome provides insights into life in the bile duct |
title_fullStr | The Opisthorchis viverrini genome provides insights into life in the bile duct |
title_full_unstemmed | The Opisthorchis viverrini genome provides insights into life in the bile duct |
title_short | The Opisthorchis viverrini genome provides insights into life in the bile duct |
title_sort | opisthorchis viverrini genome provides insights into life in the bile duct |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104445/ https://www.ncbi.nlm.nih.gov/pubmed/25007141 http://dx.doi.org/10.1038/ncomms5378 |
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