H(2)S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an...

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Detalles Bibliográficos
Autores principales: Eberhardt, Mirjam, Dux, Maria, Namer, Barbara, Miljkovic, Jan, Cordasic, Nada, Will, Christine, Kichko, Tatjana I., de la Roche, Jeanne, Fischer, Michael, Suárez, Sebastián A., Bikiel, Damian, Dorsch, Karola, Leffler, Andreas, Babes, Alexandru, Lampert, Angelika, Lennerz, Jochen K., Jacobi, Johannes, Martí, Marcelo A., Doctorovich, Fabio, Högestätt, Edward D., Zygmunt, Peter M., Ivanovic-Burmazovic, Ivana, Messlinger, Karl, Reeh, Peter, Filipovic, Milos R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104458/
https://www.ncbi.nlm.nih.gov/pubmed/25023795
http://dx.doi.org/10.1038/ncomms5381

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