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Emerging novel concept of chaperone therapies for protein misfolding diseases
Chaperone therapy is a newly developed molecular therapeutic approach to protein misfolding diseases. Among them we found unstable mutant enzyme proteins in a few lysosomal diseases, resulting in rapid intracellular degradation and loss of function. Active-site binding low molecular competitive inhi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japan Academy
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104511/ https://www.ncbi.nlm.nih.gov/pubmed/24814990 http://dx.doi.org/10.2183/pjab.90.145 |