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PKM2 Regulates the Warburg Effect and Promotes HMGB1 Release in Sepsis

Increasing evidence suggests the important role of metabolic reprogramming in the regulation of the innate inflammatory response, but the underlying mechanism remains unclear. Here, we provide evidence to support a novel role for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic...

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Detalles Bibliográficos
Autores principales:	Yang, Liangchun, Xie, Min, Yang, Minghua, Yu, Yan, Zhu, Shan, Hou, Wen, Kang, Rui, Lotze, Michael, Billiar, Timothy R., Wang, Haichao, Cao, Lizhi, Tang, Daolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104986/ https://www.ncbi.nlm.nih.gov/pubmed/25019241 http://dx.doi.org/10.1038/ncomms5436

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