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Concerted versus Stepwise Mechanism in Thymidylate Synthase

[Image: see text] Thymidylate synthase (TSase) catalyzes the intracellular de novo formation of thymidylate (a DNA building block) in most living organisms, making it a common target for chemotherapeutic and antibiotic drugs. Two mechanisms have been proposed for the rate-limiting hydride transfer s...

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Detalles Bibliográficos
Autores principales:	Islam, Zahidul, Strutzenberg, Timothy S., Gurevic, Ilya, Kohen, Amnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105062/ https://www.ncbi.nlm.nih.gov/pubmed/24949852 http://dx.doi.org/10.1021/ja504341g

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