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Structural Heterogeneity in Transmembrane Amyloid Precursor Protein Homodimer Is a Consequence of Environmental Selection

[Image: see text] The 99 amino acid C-terminal fragment of amyloid precursor protein (C99), consisting of a single transmembrane (TM) helix, is known to form homodimers. Homodimers can be processed by γ-secretase to produce amyloid-β (Aβ) protein, which is implicated in Alzheimer’s disease (AD). Whi...

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Detalles Bibliográficos
Autores principales:	Dominguez, Laura, Foster, Leigh, Meredith, Stephen C., Straub, John E., Thirumalai, D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105063/ https://www.ncbi.nlm.nih.gov/pubmed/24926593 http://dx.doi.org/10.1021/ja503150x

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