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Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status

BACKGROUND: The aim of this study was to investigate the relationship between salivary concentration of the soluble fragment of the HER2 (human epidermal growth factor receptor) protein and its status in mammary tissues. METHODS: This case-control study was done in 27 breast cancer patients with no...

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Autores principales: Laidi, Fatna, Bouziane, Amal, Lakhdar, Amina, Khabouze, Samira, Rhrab, Brahim, Zaoui, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105270/
https://www.ncbi.nlm.nih.gov/pubmed/25053886
http://dx.doi.org/10.2147/OTT.S64230
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author Laidi, Fatna
Bouziane, Amal
Lakhdar, Amina
Khabouze, Samira
Rhrab, Brahim
Zaoui, Fatima
author_facet Laidi, Fatna
Bouziane, Amal
Lakhdar, Amina
Khabouze, Samira
Rhrab, Brahim
Zaoui, Fatima
author_sort Laidi, Fatna
collection PubMed
description BACKGROUND: The aim of this study was to investigate the relationship between salivary concentration of the soluble fragment of the HER2 (human epidermal growth factor receptor) protein and its status in mammary tissues. METHODS: This case-control study was done in 27 breast cancer patients with no visible metastatic disease treated at the gynecology service, Maternity Souissi Hospital, Rabat, Morocco. Two groups were selected, ie, patients with positive and negative HER2 status in mammary tissue. The salivary HER2 protein concentration was assessed by enzyme-linked immunosorbent assay. The salivary HER2 concentration was compared between the HER2-positive and HER2-negative groups using the Mann-Whitney U test. A P-value <0.05 was considered to be statistically significant. RESULTS: No statistically significant difference in salivary HER2 protein expression was found between the case and control groups. There was also no significant difference in clinical characteristics according to positive and negative HER2 status (P>0.05), except for the progesterone hormone receptor which was statistically significant in both the case and control groups (P=0.047). CONCLUSION: According to our data, salivary expression of the HER2 receptor may not be a reliable alternative to tissue assessment.
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spelling pubmed-41052702014-07-22 Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status Laidi, Fatna Bouziane, Amal Lakhdar, Amina Khabouze, Samira Rhrab, Brahim Zaoui, Fatima Onco Targets Ther Original Research BACKGROUND: The aim of this study was to investigate the relationship between salivary concentration of the soluble fragment of the HER2 (human epidermal growth factor receptor) protein and its status in mammary tissues. METHODS: This case-control study was done in 27 breast cancer patients with no visible metastatic disease treated at the gynecology service, Maternity Souissi Hospital, Rabat, Morocco. Two groups were selected, ie, patients with positive and negative HER2 status in mammary tissue. The salivary HER2 protein concentration was assessed by enzyme-linked immunosorbent assay. The salivary HER2 concentration was compared between the HER2-positive and HER2-negative groups using the Mann-Whitney U test. A P-value <0.05 was considered to be statistically significant. RESULTS: No statistically significant difference in salivary HER2 protein expression was found between the case and control groups. There was also no significant difference in clinical characteristics according to positive and negative HER2 status (P>0.05), except for the progesterone hormone receptor which was statistically significant in both the case and control groups (P=0.047). CONCLUSION: According to our data, salivary expression of the HER2 receptor may not be a reliable alternative to tissue assessment. Dove Medical Press 2014-07-14 /pmc/articles/PMC4105270/ /pubmed/25053886 http://dx.doi.org/10.2147/OTT.S64230 Text en © 2014 Laidi et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.
spellingShingle Original Research
Laidi, Fatna
Bouziane, Amal
Lakhdar, Amina
Khabouze, Samira
Rhrab, Brahim
Zaoui, Fatima
Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
title Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
title_full Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
title_fullStr Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
title_full_unstemmed Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
title_short Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
title_sort salivary expression of soluble her2 in breast cancer patients with positive and negative her2 status
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105270/
https://www.ncbi.nlm.nih.gov/pubmed/25053886
http://dx.doi.org/10.2147/OTT.S64230
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