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Ultraviolet A-Induced Cathepsin K Expression Is Mediated via MAPK/AP-1 Pathway in Human Dermal Fibroblasts

BACKGROUND: Cathepsin K (CatK), a cysteine protease with the potent elastolytic activity, plays a predominant role in intracellular elastin degradation in human dermal fibroblasts (HDFs), and contributes to solar elastosis. In previous studies, CatK expression was downregulated in photoaged skin and...

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Detalles Bibliográficos
Autores principales:	Xu, Qingfang, Hou, Wei, Zheng, Yue, Liu, Chen, Gong, Zijian, Lu, Chun, Lai, Wei, Maibach, Howard I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105408/ https://www.ncbi.nlm.nih.gov/pubmed/25048708 http://dx.doi.org/10.1371/journal.pone.0102732

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