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Vitamin A Intake and Risk of Melanoma: A Meta-Analysis

BACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the...

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Autores principales: Zhang, Yun-Ping, Chu, Rui-Xue, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105469/
https://www.ncbi.nlm.nih.gov/pubmed/25048246
http://dx.doi.org/10.1371/journal.pone.0102527
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author Zhang, Yun-Ping
Chu, Rui-Xue
Liu, Hui
author_facet Zhang, Yun-Ping
Chu, Rui-Xue
Liu, Hui
author_sort Zhang, Yun-Ping
collection PubMed
description BACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis. METHODS: Eligible studies were identified by searching PubMed and EMBASE databases, as well as by reviewing the references of retrieved publications. Summary odds ratios (OR) with corresponding 95% confidence interval (CI) were computed with a random-effects model. Study-specific ORs and 95% CIs for the highest vs. lowest categories of vitamin A intake were pooled. RESULTS: A total of 8 case-control studies and 2 prospective studies comprising 3,328 melanoma cases and 233,295 non-case subjects were included. The summary OR for the highest compared with the lowest intake of total vitamin A, retinol and beta-carotene was 0.86 (95% CI = 0.59–1.25), 0.80 (95% CI = 0.69–0.92) and 0.87 (95%CI = 0.62–1.20), respectively. Significant heterogeneity was observed among studies on vitamin A and beta-carotene intake, but not among studies on retinol intake. Subgroup and sensitivity analyses confirmed these findings. There was no indication of publication bias. CONCLUSION: Findings from this meta-analysis suggest that intake of retinol, rather than of total vitamin A or beta-carotene, is significantly associated with reduced risk of melanoma.
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spelling pubmed-41054692014-07-23 Vitamin A Intake and Risk of Melanoma: A Meta-Analysis Zhang, Yun-Ping Chu, Rui-Xue Liu, Hui PLoS One Research Article BACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis. METHODS: Eligible studies were identified by searching PubMed and EMBASE databases, as well as by reviewing the references of retrieved publications. Summary odds ratios (OR) with corresponding 95% confidence interval (CI) were computed with a random-effects model. Study-specific ORs and 95% CIs for the highest vs. lowest categories of vitamin A intake were pooled. RESULTS: A total of 8 case-control studies and 2 prospective studies comprising 3,328 melanoma cases and 233,295 non-case subjects were included. The summary OR for the highest compared with the lowest intake of total vitamin A, retinol and beta-carotene was 0.86 (95% CI = 0.59–1.25), 0.80 (95% CI = 0.69–0.92) and 0.87 (95%CI = 0.62–1.20), respectively. Significant heterogeneity was observed among studies on vitamin A and beta-carotene intake, but not among studies on retinol intake. Subgroup and sensitivity analyses confirmed these findings. There was no indication of publication bias. CONCLUSION: Findings from this meta-analysis suggest that intake of retinol, rather than of total vitamin A or beta-carotene, is significantly associated with reduced risk of melanoma. Public Library of Science 2014-07-21 /pmc/articles/PMC4105469/ /pubmed/25048246 http://dx.doi.org/10.1371/journal.pone.0102527 Text en © 2014 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Yun-Ping
Chu, Rui-Xue
Liu, Hui
Vitamin A Intake and Risk of Melanoma: A Meta-Analysis
title Vitamin A Intake and Risk of Melanoma: A Meta-Analysis
title_full Vitamin A Intake and Risk of Melanoma: A Meta-Analysis
title_fullStr Vitamin A Intake and Risk of Melanoma: A Meta-Analysis
title_full_unstemmed Vitamin A Intake and Risk of Melanoma: A Meta-Analysis
title_short Vitamin A Intake and Risk of Melanoma: A Meta-Analysis
title_sort vitamin a intake and risk of melanoma: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105469/
https://www.ncbi.nlm.nih.gov/pubmed/25048246
http://dx.doi.org/10.1371/journal.pone.0102527
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