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ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice

We previously demonstrated that macrophages exhibit endoplasmic reticulum fragmentation under cholesterol-rich conditions, which results in the generation of acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1)-associated late endosomes/lysosomes (ACAT1-LE). ACAT1-LE efficiently esterify free chol...

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Detalles Bibliográficos
Autores principales:	Kamikawa, Masashi, Lei, XiaoFeng, Fujiwara, Yukio, Nishitsuji, Kazuchika, Mizuta, Hiroshi, Takeya, Motohiro, Sakashita, Naomi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japan Society of Histochemistry and Cytochemistry 2014
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105798/ https://www.ncbi.nlm.nih.gov/pubmed/25221362 http://dx.doi.org/10.1267/ahc.13033

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