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The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population

BACKGROUND: Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians...

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Autores principales: Мirrakhimov, Erkin М, Kerimkulova, Alina S, Lunegova, Оlga S, Mirrakhimov, Aibek E, Nabiev, Malik P, Neronova, Kseniya V, Bayramukova, Asiyat A, Alibaeva, Nazira T, Satarov, Nurdin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105887/
https://www.ncbi.nlm.nih.gov/pubmed/24981337
http://dx.doi.org/10.1186/1756-0500-7-411
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author Мirrakhimov, Erkin М
Kerimkulova, Alina S
Lunegova, Оlga S
Mirrakhimov, Aibek E
Nabiev, Malik P
Neronova, Kseniya V
Bayramukova, Asiyat A
Alibaeva, Nazira T
Satarov, Nurdin
author_facet Мirrakhimov, Erkin М
Kerimkulova, Alina S
Lunegova, Оlga S
Mirrakhimov, Aibek E
Nabiev, Malik P
Neronova, Kseniya V
Bayramukova, Asiyat A
Alibaeva, Nazira T
Satarov, Nurdin
author_sort Мirrakhimov, Erkin М
collection PubMed
description BACKGROUND: Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. RESULTS: In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. CONCLUSION: Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients.
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spelling pubmed-41058872014-07-23 The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population Мirrakhimov, Erkin М Kerimkulova, Alina S Lunegova, Оlga S Mirrakhimov, Aibek E Nabiev, Malik P Neronova, Kseniya V Bayramukova, Asiyat A Alibaeva, Nazira T Satarov, Nurdin BMC Res Notes Research Article BACKGROUND: Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. RESULTS: In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. CONCLUSION: Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. BioMed Central 2014-06-30 /pmc/articles/PMC4105887/ /pubmed/24981337 http://dx.doi.org/10.1186/1756-0500-7-411 Text en Copyright © 2014 Мirrakhimov et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Мirrakhimov, Erkin М
Kerimkulova, Alina S
Lunegova, Оlga S
Mirrakhimov, Aibek E
Nabiev, Malik P
Neronova, Kseniya V
Bayramukova, Asiyat A
Alibaeva, Nazira T
Satarov, Nurdin
The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
title The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
title_full The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
title_fullStr The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
title_full_unstemmed The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
title_short The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
title_sort association of leptin with dyslipidemia, arterial hypertension and obesity in kyrgyz (central asian nation) population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105887/
https://www.ncbi.nlm.nih.gov/pubmed/24981337
http://dx.doi.org/10.1186/1756-0500-7-411
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