PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer

Upon analysis of 636 primary breast carcinoma patient samples, we have found that programmed cell death ligand 1 (PD-L1) mRNA expression is associated with tumor-infiltrating lymphocytes (TILs). Furthermore, PD-L1 expression and elevated TILs were associated with longer recurrence-free survival. Thu...

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Detalles Bibliográficos
Autor principal: Schalper, Kurt A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106164/
https://www.ncbi.nlm.nih.gov/pubmed/25083339
http://dx.doi.org/10.4161/onci.29288
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author Schalper, Kurt A
author_facet Schalper, Kurt A
author_sort Schalper, Kurt A
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description Upon analysis of 636 primary breast carcinoma patient samples, we have found that programmed cell death ligand 1 (PD-L1) mRNA expression is associated with tumor-infiltrating lymphocytes (TILs). Furthermore, PD-L1 expression and elevated TILs were associated with longer recurrence-free survival. Thus, our findings indicate that PD-L1 is prognostic in breast cancer and suggests a functional link between TILs and tumor PD-L1 upregulation.
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spelling pubmed-41061642014-07-31 PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer Schalper, Kurt A Oncoimmunology Author's View Upon analysis of 636 primary breast carcinoma patient samples, we have found that programmed cell death ligand 1 (PD-L1) mRNA expression is associated with tumor-infiltrating lymphocytes (TILs). Furthermore, PD-L1 expression and elevated TILs were associated with longer recurrence-free survival. Thus, our findings indicate that PD-L1 is prognostic in breast cancer and suggests a functional link between TILs and tumor PD-L1 upregulation. Landes Bioscience 2014-06-25 /pmc/articles/PMC4106164/ /pubmed/25083339 http://dx.doi.org/10.4161/onci.29288 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Schalper, Kurt A
PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
title PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
title_full PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
title_fullStr PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
title_full_unstemmed PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
title_short PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
title_sort pd-l1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106164/
https://www.ncbi.nlm.nih.gov/pubmed/25083339
http://dx.doi.org/10.4161/onci.29288
work_keys_str_mv AT schalperkurta pdl1expressionandtumorinfiltratinglymphocytesrevisitingtheantitumorimmuneresponsepotentialinbreastcancer

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