CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?

Chimeric antigen receptor (CAR) modified T cells have emerged as powerful tools for controlling leukemias. We recently showed that anti-CD123 CAR-expressing cytokine-induced killer T cell treatment is an effective immunotherapeutic approach to eradicate Acute Myeloid Leukemia (AML) cells. Here, we d...

Descripción completa

Detalles Bibliográficos
Autores principales: Tettamanti, Sarah, Biondi, Andrea, Biagi, Ettore, Bonnet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106165/
https://www.ncbi.nlm.nih.gov/pubmed/25083319
http://dx.doi.org/10.4161/onci.28835
_version_ 1782327483535720448
author Tettamanti, Sarah
Biondi, Andrea
Biagi, Ettore
Bonnet, Dominique
author_facet Tettamanti, Sarah
Biondi, Andrea
Biagi, Ettore
Bonnet, Dominique
author_sort Tettamanti, Sarah
collection PubMed
description Chimeric antigen receptor (CAR) modified T cells have emerged as powerful tools for controlling leukemias. We recently showed that anti-CD123 CAR-expressing cytokine-induced killer T cell treatment is an effective immunotherapeutic approach to eradicate Acute Myeloid Leukemia (AML) cells. Here, we discuss how this genetically modified cell-based strategy could be relevant to the field of AML therapeutics.
format Online
Article
Text
id pubmed-4106165
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-41061652014-07-31 CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics? Tettamanti, Sarah Biondi, Andrea Biagi, Ettore Bonnet, Dominique Oncoimmunology Author's View Chimeric antigen receptor (CAR) modified T cells have emerged as powerful tools for controlling leukemias. We recently showed that anti-CD123 CAR-expressing cytokine-induced killer T cell treatment is an effective immunotherapeutic approach to eradicate Acute Myeloid Leukemia (AML) cells. Here, we discuss how this genetically modified cell-based strategy could be relevant to the field of AML therapeutics. Landes Bioscience 2014-05-14 /pmc/articles/PMC4106165/ /pubmed/25083319 http://dx.doi.org/10.4161/onci.28835 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Tettamanti, Sarah
Biondi, Andrea
Biagi, Ettore
Bonnet, Dominique
CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
title CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
title_full CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
title_fullStr CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
title_full_unstemmed CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
title_short CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
title_sort cd123 aml targeting by chimeric antigen receptors: a novel magic bullet for aml therapeutics?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106165/
https://www.ncbi.nlm.nih.gov/pubmed/25083319
http://dx.doi.org/10.4161/onci.28835
work_keys_str_mv AT tettamantisarah cd123amltargetingbychimericantigenreceptorsanovelmagicbulletforamltherapeutics
AT biondiandrea cd123amltargetingbychimericantigenreceptorsanovelmagicbulletforamltherapeutics
AT biagiettore cd123amltargetingbychimericantigenreceptorsanovelmagicbulletforamltherapeutics
AT bonnetdominique cd123amltargetingbychimericantigenreceptorsanovelmagicbulletforamltherapeutics

Ejemplares similares