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Dasatinib promotes Th1-type responses in granzyme B expressing T-cells

Tyrosine kinase inhibitors (TKIs) have dramatically improved the outcome of chronic myeloid leukemia (CML). Besides inhibiting target kinases in leukemic cells, 2nd generation TKI dasatinib also inhibits off-targets in immune effector cells resulting in atypical immune responses in some patients. Da...

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Detalles Bibliográficos
Autores principales:	Kreutzman, Anna, Ilander, Mette, Porkka, Kimmo, Vakkila, Jukka, Mustjoki, Satu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106168/ https://www.ncbi.nlm.nih.gov/pubmed/25083322 http://dx.doi.org/10.4161/onci.28925

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