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An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
INTRODUCTION: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardia...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106213/ https://www.ncbi.nlm.nih.gov/pubmed/25023062 http://dx.doi.org/10.1186/1752-1947-8-252 |
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author | Atalay, Figen Gulmez, Oyku Ozsancak Ugurlu, Aylin |
author_facet | Atalay, Figen Gulmez, Oyku Ozsancak Ugurlu, Aylin |
author_sort | Atalay, Figen |
collection | PubMed |
description | INTRODUCTION: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. CASE PRESENTATION: A 66-year-old Caucasian woman with a mediastinal mass diagnosed with Burkitt lymphoma underwent chemotherapy with rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone. On the seventh day of chemotherapy, she developed dyspnea. An electrocardiogram demonstrated low voltage in the limb and precordial leads. It also showed diffusely increased myocardial echogenicity, mild pericardial and pleural effusion, generally impaired biventricular systolic functions with a left ventricular ejection fraction of 31%, and right ventricular mid-apical akinesia, even though she had normal biventricular functions before chemotherapy. Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function. After 1 month, echocardiography showed normal biventricular functions with a left ventricular ejection fraction of 60%. CONCLUSIONS: Drug-induced cardiotoxicity, therefore, should be taken into consideration when using cyclophosphamide therapy, especially when anthracyclines are co-administered. Close communication between hematologists and cardiologists is required. |
format | Online Article Text |
id | pubmed-4106213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41062132014-07-23 An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report Atalay, Figen Gulmez, Oyku Ozsancak Ugurlu, Aylin J Med Case Rep Case Report INTRODUCTION: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. CASE PRESENTATION: A 66-year-old Caucasian woman with a mediastinal mass diagnosed with Burkitt lymphoma underwent chemotherapy with rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone. On the seventh day of chemotherapy, she developed dyspnea. An electrocardiogram demonstrated low voltage in the limb and precordial leads. It also showed diffusely increased myocardial echogenicity, mild pericardial and pleural effusion, generally impaired biventricular systolic functions with a left ventricular ejection fraction of 31%, and right ventricular mid-apical akinesia, even though she had normal biventricular functions before chemotherapy. Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function. After 1 month, echocardiography showed normal biventricular functions with a left ventricular ejection fraction of 60%. CONCLUSIONS: Drug-induced cardiotoxicity, therefore, should be taken into consideration when using cyclophosphamide therapy, especially when anthracyclines are co-administered. Close communication between hematologists and cardiologists is required. BioMed Central 2014-07-14 /pmc/articles/PMC4106213/ /pubmed/25023062 http://dx.doi.org/10.1186/1752-1947-8-252 Text en Copyright © 2014 Atalay et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Atalay, Figen Gulmez, Oyku Ozsancak Ugurlu, Aylin An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
title | An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
title_full | An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
title_fullStr | An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
title_full_unstemmed | An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
title_short | An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
title_sort | unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106213/ https://www.ncbi.nlm.nih.gov/pubmed/25023062 http://dx.doi.org/10.1186/1752-1947-8-252 |
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