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An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report

INTRODUCTION: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardia...

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Autores principales: Atalay, Figen, Gulmez, Oyku, Ozsancak Ugurlu, Aylin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106213/
https://www.ncbi.nlm.nih.gov/pubmed/25023062
http://dx.doi.org/10.1186/1752-1947-8-252
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author Atalay, Figen
Gulmez, Oyku
Ozsancak Ugurlu, Aylin
author_facet Atalay, Figen
Gulmez, Oyku
Ozsancak Ugurlu, Aylin
author_sort Atalay, Figen
collection PubMed
description INTRODUCTION: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. CASE PRESENTATION: A 66-year-old Caucasian woman with a mediastinal mass diagnosed with Burkitt lymphoma underwent chemotherapy with rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone. On the seventh day of chemotherapy, she developed dyspnea. An electrocardiogram demonstrated low voltage in the limb and precordial leads. It also showed diffusely increased myocardial echogenicity, mild pericardial and pleural effusion, generally impaired biventricular systolic functions with a left ventricular ejection fraction of 31%, and right ventricular mid-apical akinesia, even though she had normal biventricular functions before chemotherapy. Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function. After 1 month, echocardiography showed normal biventricular functions with a left ventricular ejection fraction of 60%. CONCLUSIONS: Drug-induced cardiotoxicity, therefore, should be taken into consideration when using cyclophosphamide therapy, especially when anthracyclines are co-administered. Close communication between hematologists and cardiologists is required.
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spelling pubmed-41062132014-07-23 An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report Atalay, Figen Gulmez, Oyku Ozsancak Ugurlu, Aylin J Med Case Rep Case Report INTRODUCTION: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. CASE PRESENTATION: A 66-year-old Caucasian woman with a mediastinal mass diagnosed with Burkitt lymphoma underwent chemotherapy with rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone. On the seventh day of chemotherapy, she developed dyspnea. An electrocardiogram demonstrated low voltage in the limb and precordial leads. It also showed diffusely increased myocardial echogenicity, mild pericardial and pleural effusion, generally impaired biventricular systolic functions with a left ventricular ejection fraction of 31%, and right ventricular mid-apical akinesia, even though she had normal biventricular functions before chemotherapy. Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function. After 1 month, echocardiography showed normal biventricular functions with a left ventricular ejection fraction of 60%. CONCLUSIONS: Drug-induced cardiotoxicity, therefore, should be taken into consideration when using cyclophosphamide therapy, especially when anthracyclines are co-administered. Close communication between hematologists and cardiologists is required. BioMed Central 2014-07-14 /pmc/articles/PMC4106213/ /pubmed/25023062 http://dx.doi.org/10.1186/1752-1947-8-252 Text en Copyright © 2014 Atalay et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Atalay, Figen
Gulmez, Oyku
Ozsancak Ugurlu, Aylin
An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
title An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
title_full An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
title_fullStr An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
title_full_unstemmed An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
title_short An unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
title_sort unusual presentation of an intraosseous epidermoid cyst of the anterior maxilla: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106213/
https://www.ncbi.nlm.nih.gov/pubmed/25023062
http://dx.doi.org/10.1186/1752-1947-8-252
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