Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

Several neurodegenerative diseases are characterized by the aggregation and posttranslational modifications of Tau protein. Its “repeat domain” (TauRD) is mainly responsible for the aggregation properties, and oligomeric forms are thought to dominate the toxic effects of Tau. Here we investigated th...

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Detalles Bibliográficos
Autores principales: Kumar, Satish, Tepper, Katharina, Kaniyappan, Senthilvelrajan, Biernat, Jacek, Wegmann, Susanne, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106345/
https://www.ncbi.nlm.nih.gov/pubmed/24825901
http://dx.doi.org/10.1074/jbc.M114.554725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106345/
https://www.ncbi.nlm.nih.gov/pubmed/24825901
http://dx.doi.org/10.1074/jbc.M114.554725

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