Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis)

Cyclic adenosine monophosphate (cAMP) signalling plays an important role in synaptic plasticity and information processing in the hippocampal and basal ganglia systems. The augmentation of cAMP signalling through the selective inhibition of phosphodiesterases represents a viable strategy to treat di...

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Detalles Bibliográficos
Autores principales: Sutcliffe, Jane S., Beaumont, Vahri, Watson, James M., Chew, Chang Sing, Beconi, Maria, Hutcheson, Daniel M., Dominguez, Celia, Munoz-Sanjuan, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106781/
https://www.ncbi.nlm.nih.gov/pubmed/25050979
http://dx.doi.org/10.1371/journal.pone.0102449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106781/
https://www.ncbi.nlm.nih.gov/pubmed/25050979
http://dx.doi.org/10.1371/journal.pone.0102449

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