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A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance

Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based immunother...

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Detalles Bibliográficos
Autores principales:	King, Thomas H., Kemmler, Charles B., Guo, Zhimin, Mann, Derrick, Lu, Yingnian, Coeshott, Claire, Gehring, Adam J., Bertoletti, Antonio, Ho, Zi Z., Delaney, William, Gaggar, Anuj, Subramanian, G. Mani, McHutchison, John G., Shrivastava, Shikha, Lee, Yu-Jin L., Kottilil, Shyamasundaran, Bellgrau, Donald, Rodell, Timothy, Apelian, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106793/ https://www.ncbi.nlm.nih.gov/pubmed/25051027 http://dx.doi.org/10.1371/journal.pone.0101904

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