Cargando…

A Systematic Evaluation of Short Tandem Repeats in Lipid Candidate Genes: Riding on the SNP-Wave

Structural genetic variants as short tandem repeats (STRs) are not targeted in SNP-based association studies and thus, their possible association signals are missed. We systematically searched for STRs in gene regions known to contribute to total cholesterol, HDL cholesterol, LDL cholesterol and tri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lamina, Claudia, Haun, Margot, Coassin, Stefan, Kloss-Brandstätter, Anita, Gieger, Christian, Peters, Annette, Grallert, Harald, Strauch, Konstantin, Meitinger, Thomas, Kedenko, Lyudmyla, Paulweber, Bernhard, Kronenberg, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106801/ https://www.ncbi.nlm.nih.gov/pubmed/25050552 http://dx.doi.org/10.1371/journal.pone.0102113

Ejemplares similares

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter
por: Coassin, Stefan, et al.
Publicado: (2020)

Candidate Gene Sequencing of SLC11A2 and TMPRSS6 in a Family with Severe Anaemia: Common SNPs, Rare Haplotypes, No Causative Mutation
por: Kloss-Brandstätter, Anita, et al.
Publicado: (2012)

Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort
por: Kedenko, Lyudmyla, et al.
Publicado: (2014)

Investigation and Functional Characterization of Rare Genetic Variants in the Adipose Triglyceride Lipase in a Large Healthy Working Population
por: Coassin, Stefan, et al.
Publicado: (2010)

Polymorphisms in the Gene Regions of the Adaptor Complex LAMTOR2/LAMTOR3 and Their Association with Breast Cancer Risk
por: De Araujo, Mariana E., et al.
Publicado: (2013)

Influence of DNA extraction methods on relative telomere length measurements and its impact on epidemiological studies
por: Raschenberger, Julia, et al.
Publicado: (2016)

Genetic Polymorphisms of the Main Transcription Factors for Adiponectin Gene Promoter in Regulation of Adiponectin Levels: Association Analysis in Three European Cohorts
por: Kedenko, Lyudmyla, et al.
Publicado: (2012)

SNPflow: A Lightweight Application for the Processing, Storing and Automatic Quality Checking of Genotyping Assays
por: Weissensteiner, Hansi, et al.
Publicado: (2013)

Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns
por: Erhart, Gertraud, et al.
Publicado: (2018)

A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study
por: Duschek, Elena, et al.
Publicado: (2023)

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
por: Mack, Salome, et al.
Publicado: (2017)

A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region
por: Coassin, Stefan, et al.
Publicado: (2019)

A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction
por: Coassin, Stefan, et al.
Publicado: (2017)

The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat
por: Grüneis, Rebecca, et al.
Publicado: (2022)

A genome-wide association meta-analysis on apolipoprotein A-IV concentrations
por: Lamina, Claudia, et al.
Publicado: (2016)

Mitochondrial Genetic Variants Identified to Be Associated with BMI in Adults
por: Flaquer, Antònia, et al.
Publicado: (2014)

An optimized procedure for the design and evaluation of Ecotilling assays
por: Coassin, Stefan, et al.
Publicado: (2008)

The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A
por: Grüneis, Rebecca, et al.
Publicado: (2022)

Mitochondrial GWA Analysis of Lipid Profile Identifies Genetic Variants to Be Associated with HDL Cholesterol and Triglyceride Levels
por: Flaquer, Antònia, et al.
Publicado: (2015)

pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms
por: Molnos, Sophie, et al.
Publicado: (2017)

Is High-Density Lipoprotein Cholesterol Causally Related to Kidney Function?: Evidence From Genetic Epidemiological Studies
por: Coassin, Stefan, et al.
Publicado: (2016)

Evaluating the Causal Relation of ApoA-IV with Disease-Related Traits - A Bidirectional Two-sample Mendelian Randomization Study
por: Mack, Salome, et al.
Publicado: (2017)

Lipoprotein(a) and SARS-CoV-2 infections: Risk for ischemic heart disease and thromboembolic events
por: Di Maio, S., et al.
Publicado: (2022)

eCOMPAGT – efficient Combination and Management of Phenotypes and Genotypes for Genetic Epidemiology
por: Schönherr, Sebastian, et al.
Publicado: (2009)

The Single Nucleotide Polymorphism Gly482Ser in the PGC-1α Gene Impairs Exercise-Induced Slow-Twitch Muscle Fibre Transformation in Humans
por: Steinbacher, Peter, et al.
Publicado: (2015)

CONAN: copy number variation analysis software for genome-wide association studies
por: Forer, Lukas, et al.
Publicado: (2010)

Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene
por: Coassin, Stefan, et al.
Publicado: (2022)

Lipoprotein(a) and SARS‐CoV‐2 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events
por: Di Maio, Silvia, et al.
Publicado: (2021)

Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease
por: Schachtl-Riess, Johanna F., et al.
Publicado: (2021)

Cloudgene: A graphical execution platform for MapReduce programs on private and public clouds
por: Schönherr, Sebastian, et al.
Publicado: (2012)

Lysis reagents, cell numbers, and calculation method influence high-throughput measurement of HDL-mediated cholesterol efflux capacity
por: Schachtl-Riess, Johanna F., et al.
Publicado: (2021)

Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein(a) in 10,910 individuals
por: Di Maio, Silvia, et al.
Publicado: (2020)

Network reconstruction for trans acting genetic loci using multi-omics data and prior information
por: Hawe, Johann S., et al.
Publicado: (2022)

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns
por: Wahl, Annika, et al.
Publicado: (2018)

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
por: Do, Kieu Trinh, et al.
Publicado: (2018)

Comparison of allogeneic and autogenous bone grafts for augmentation of alveolar ridge defects—A 12‐month retrospective radiographic evaluation
por: Kloss, Frank R., et al.
Publicado: (2018)

Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts
por: Laschkolnig, Anja, et al.
Publicado: (2014)

First Clinical Case Report of a Xenograft–Allograft Combination for Alveolar Ridge Augmentation Using a Bovine Bone Substitute Material with Hyaluronate (Cerabone(®) Plus) Combined with Allogeneic Bone Granules (Maxgraft(®))
por: Kloss, Frank R., et al.
Publicado: (2023)

Risk Factors for Complications Following Staged Alveolar Ridge Augmentation and Dental Implantation: A Retrospective Evaluation of 151 Cases with Allogeneic and 70 Cases with Autogenous Bone Blocks
por: Kloss, Frank R., et al.
Publicado: (2022)

mtDNA-Server: next-generation sequencing data analysis of human mitochondrial DNA in the cloud
por: Weissensteiner, Hansi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dmhgdmq1mu3nsbc5rf3nknfa2c