The effects of aging on lymphocyte subgroups in males and females

BACKGROUND: Age-associated immune senescence is a catch-all phrase that has been used to describe a plethora of changes to the immune system across the lifespan. Aging is associated with a decline in immune function. Our aim in this study was to investigate how lymphocyte subgroups in peripheral blo...

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Detalles Bibliográficos
Autores principales: Inal, Ali, Koç, Bora, Bircan, Huseyin Yuce, Ogan, Ebru, Yavuz, Alpaslan, Kemik, Ozgur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106926/
https://www.ncbi.nlm.nih.gov/pubmed/25033372
http://dx.doi.org/10.12659/MSMBR.891239
Descripción
Sumario:BACKGROUND: Age-associated immune senescence is a catch-all phrase that has been used to describe a plethora of changes to the immune system across the lifespan. Aging is associated with a decline in immune function. Our aim in this study was to investigate how lymphocyte subgroups in peripheral blood are affected by aging among males and females. MATERIAL/METHODS: Study participants were 70 healthy individuals from 3 different age groups, observed from January 2010 to January 2012. The average levels of CD3+, CD4+, CD8+, CD19+, CD16+/CD56+, CD3+/CD69+, and CD19+/CD69+ were determined for each group and compared in terms of age and sex. RESULTS: We found significant reduction in the level of CD3+T cells related with age, but no significant changes in CD19+ B cell levels (p<0.005). Aging significantly reduces activated B cell (CD19+/CD69+) levels in males (p<0.005). CONCLUSIONS: Our results show that there may be differences between males and females in terms of immune senescence.

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