Cargando…
Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China
INTRODUCTION: Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral m...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107257/ https://www.ncbi.nlm.nih.gov/pubmed/25097582 http://dx.doi.org/10.5114/aoms.2014.43745 |
_version_ | 1782327573925068800 |
---|---|
author | Wang, Qi Zhang, Weidong Zhang, Ying Yan, Lei Wang, Shiwen Zhang, Jing Sun, Junling Chang, Zhaorui Wang, Zijun |
author_facet | Wang, Qi Zhang, Weidong Zhang, Ying Yan, Lei Wang, Shiwen Zhang, Jing Sun, Junling Chang, Zhaorui Wang, Zijun |
author_sort | Wang, Qi |
collection | PubMed |
description | INTRODUCTION: Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS: A case control study was conducted in a designated hospital to compare severe and mild cases of patients infected with the EV71 virus. Demographic information along with clinical features of HFMD was collected through a standardized questionnaire. Multi-factorial logistic regression was used to analyze independent associations between potential risk factors and severe HFMD. RESULTS: There were 120 cases (60 cases and 60 controls) collected. The male-to-female ratio was 1.3: 1 in the case group and 1.7: 1 in the control group. Multi-factorial logistic regression revealed that the main risk factors for severe cases were highest body temperature being ≥ 38.5°C (OR = 9.45, 95% CI: 2.07–43.11, p < 0.05), first visited a village level clinic (OR = 4.72, 95% CI: 1.15–19.45, p < 0.05), etc. CONCLUSIONS: Close surveillance combined with laboratory testing should be in place during the epidemic period of HFMD. Grass root level medical facilities and training of clinical and laboratory staff should be reinforced so that the diagnostic and treatment capacity can be improved. |
format | Online Article Text |
id | pubmed-4107257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-41072572014-08-05 Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China Wang, Qi Zhang, Weidong Zhang, Ying Yan, Lei Wang, Shiwen Zhang, Jing Sun, Junling Chang, Zhaorui Wang, Zijun Arch Med Sci Clinical Research INTRODUCTION: Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS: A case control study was conducted in a designated hospital to compare severe and mild cases of patients infected with the EV71 virus. Demographic information along with clinical features of HFMD was collected through a standardized questionnaire. Multi-factorial logistic regression was used to analyze independent associations between potential risk factors and severe HFMD. RESULTS: There were 120 cases (60 cases and 60 controls) collected. The male-to-female ratio was 1.3: 1 in the case group and 1.7: 1 in the control group. Multi-factorial logistic regression revealed that the main risk factors for severe cases were highest body temperature being ≥ 38.5°C (OR = 9.45, 95% CI: 2.07–43.11, p < 0.05), first visited a village level clinic (OR = 4.72, 95% CI: 1.15–19.45, p < 0.05), etc. CONCLUSIONS: Close surveillance combined with laboratory testing should be in place during the epidemic period of HFMD. Grass root level medical facilities and training of clinical and laboratory staff should be reinforced so that the diagnostic and treatment capacity can be improved. Termedia Publishing House 2014-06-27 2014-06-29 /pmc/articles/PMC4107257/ /pubmed/25097582 http://dx.doi.org/10.5114/aoms.2014.43745 Text en Copyright © 2014 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Wang, Qi Zhang, Weidong Zhang, Ying Yan, Lei Wang, Shiwen Zhang, Jing Sun, Junling Chang, Zhaorui Wang, Zijun Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China |
title | Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China |
title_full | Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China |
title_fullStr | Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China |
title_full_unstemmed | Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China |
title_short | Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China |
title_sort | clinical features of severe cases of hand, foot and mouth disease with ev71 virus infection in china |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107257/ https://www.ncbi.nlm.nih.gov/pubmed/25097582 http://dx.doi.org/10.5114/aoms.2014.43745 |
work_keys_str_mv | AT wangqi clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT zhangweidong clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT zhangying clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT yanlei clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT wangshiwen clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT zhangjing clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT sunjunling clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT changzhaorui clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina AT wangzijun clinicalfeaturesofseverecasesofhandfootandmouthdiseasewithev71virusinfectioninchina |