A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

The central importance of translational control by post-translational modification has spurred major interest in regulatory pathways that control translation. One such pathway uniquely adds hypusine to eukaryotic initiation factor 5A (eIF5A), and thereby affects protein synthesis and, subsequently,...

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Detalles Bibliográficos
Autores principales: Sievert, Henning, Pällmann, Nora, Miller, Katharine K., Hermans-Borgmeyer, Irm, Venz, Simone, Sendoel, Ataman, Preukschas, Michael, Schweizer, Michaela, Boettcher, Steffen, Janiesch, P. Christoph, Streichert, Thomas, Walther, Reinhard, Hengartner, Michael O., Manz, Markus G., Brümmendorf, Tim H., Bokemeyer, Carsten, Braig, Melanie, Hauber, Joachim, Duncan, Kent E., Balabanov, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107325/
https://www.ncbi.nlm.nih.gov/pubmed/24832488
http://dx.doi.org/10.1242/dmm.014449

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