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Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis

BACKGROUND: Chronic painful conditions have an important influence on the ability to work. Work-related outcomes, however, are not commonly reported in publications on trials investigating the treatment of chronic painful conditions. We aim to provide an overview of the reporting of work-related out...

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Autores principales: Wolf, Ingmar, Friede, Tim, Hallier, Ernst, Straube, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107475/
https://www.ncbi.nlm.nih.gov/pubmed/25057282
http://dx.doi.org/10.1186/1745-6673-9-25
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author Wolf, Ingmar
Friede, Tim
Hallier, Ernst
Straube, Sebastian
author_facet Wolf, Ingmar
Friede, Tim
Hallier, Ernst
Straube, Sebastian
author_sort Wolf, Ingmar
collection PubMed
description BACKGROUND: Chronic painful conditions have an important influence on the ability to work. Work-related outcomes, however, are not commonly reported in publications on trials investigating the treatment of chronic painful conditions. We aim to provide an overview of the reporting of work-related outcomes in such trials and investigate the relationship between work-related outcomes and pain outcomes. METHODS: We conducted a systematic literature search in PubMed with the aim of identifying randomised placebo-controlled clinical trials investigating treatments for chronic painful conditions or rheumatic diseases that also reported on work-related outcomes. Methodological study quality was assessed with the Oxford Quality Scale (OQS). Meta-analyses were conducted for the outcomes of interference with work and number of patients with at least 30% reduction in pain intensity (30% pain responders). The correlation between work-related and pain outcomes was investigated with regression analyses. RESULTS: We included 31 publications reporting on 27 datasets from randomised placebo-controlled trials (with a total of 11,434 study participants) conducted in chronic painful or rheumatic diseases and reporting on work-related outcomes. These 31 publications make up only about 0.2% of all publications on randomised placebo-controlled trials in such conditions. The methodological quality of the included studies was high; only nine studies scored less than four (out of a maximum five) points on the OQS. Sixteen different work-related outcomes were reported on in the studies. Of 25 studies testing for the statistical significance of changes in work-related outcomes over the course of the trials, 14 (56%) reported a significant improvement; the others reported non-significant changes. Eight studies reported data on both interference with work and 30% pain responders: meta-analyses demonstrated similar, statistically significant improvements in both these outcomes with active therapy compared to placebo and regression analysis showed that these outcomes were correlated. CONCLUSIONS: Despite the importance of pain as a reason for decreased ability to work, work-related outcomes are reported in substantially less than 1% of publications on placebo-controlled trials in chronic painful and rheumatic diseases. Work-related outcomes and pain responder outcomes are closely related.
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spelling pubmed-41074752014-07-24 Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis Wolf, Ingmar Friede, Tim Hallier, Ernst Straube, Sebastian J Occup Med Toxicol Research BACKGROUND: Chronic painful conditions have an important influence on the ability to work. Work-related outcomes, however, are not commonly reported in publications on trials investigating the treatment of chronic painful conditions. We aim to provide an overview of the reporting of work-related outcomes in such trials and investigate the relationship between work-related outcomes and pain outcomes. METHODS: We conducted a systematic literature search in PubMed with the aim of identifying randomised placebo-controlled clinical trials investigating treatments for chronic painful conditions or rheumatic diseases that also reported on work-related outcomes. Methodological study quality was assessed with the Oxford Quality Scale (OQS). Meta-analyses were conducted for the outcomes of interference with work and number of patients with at least 30% reduction in pain intensity (30% pain responders). The correlation between work-related and pain outcomes was investigated with regression analyses. RESULTS: We included 31 publications reporting on 27 datasets from randomised placebo-controlled trials (with a total of 11,434 study participants) conducted in chronic painful or rheumatic diseases and reporting on work-related outcomes. These 31 publications make up only about 0.2% of all publications on randomised placebo-controlled trials in such conditions. The methodological quality of the included studies was high; only nine studies scored less than four (out of a maximum five) points on the OQS. Sixteen different work-related outcomes were reported on in the studies. Of 25 studies testing for the statistical significance of changes in work-related outcomes over the course of the trials, 14 (56%) reported a significant improvement; the others reported non-significant changes. Eight studies reported data on both interference with work and 30% pain responders: meta-analyses demonstrated similar, statistically significant improvements in both these outcomes with active therapy compared to placebo and regression analysis showed that these outcomes were correlated. CONCLUSIONS: Despite the importance of pain as a reason for decreased ability to work, work-related outcomes are reported in substantially less than 1% of publications on placebo-controlled trials in chronic painful and rheumatic diseases. Work-related outcomes and pain responder outcomes are closely related. BioMed Central 2014-07-15 /pmc/articles/PMC4107475/ /pubmed/25057282 http://dx.doi.org/10.1186/1745-6673-9-25 Text en Copyright © 2014 Wolf et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wolf, Ingmar
Friede, Tim
Hallier, Ernst
Straube, Sebastian
Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
title Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
title_full Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
title_fullStr Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
title_full_unstemmed Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
title_short Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
title_sort work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107475/
https://www.ncbi.nlm.nih.gov/pubmed/25057282
http://dx.doi.org/10.1186/1745-6673-9-25
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