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Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy

Surgery is the mainstay of treatment for gastrointestinal stromal tumors (GISTs). However, complete resection of rectal GISTs is sometimes difficult because of bulkiness and/or anatomical reasons. Neoadjuvant imatinib therapy has gained attention as an alternative treatment to increase the chance of...

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Autores principales: Nozawa, Hiroaki, Kanazawa, Takamitsu, Tanaka, Toshiaki, Takahashi, Masao, Ishihara, Soichiro, Sunami, Eiji, Kitayama, Joji, Ikemura, Masako, Komuro, Issei, Watanabe, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107559/
https://www.ncbi.nlm.nih.gov/pubmed/25022862
http://dx.doi.org/10.1186/1477-7819-12-211
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author Nozawa, Hiroaki
Kanazawa, Takamitsu
Tanaka, Toshiaki
Takahashi, Masao
Ishihara, Soichiro
Sunami, Eiji
Kitayama, Joji
Ikemura, Masako
Komuro, Issei
Watanabe, Toshiaki
author_facet Nozawa, Hiroaki
Kanazawa, Takamitsu
Tanaka, Toshiaki
Takahashi, Masao
Ishihara, Soichiro
Sunami, Eiji
Kitayama, Joji
Ikemura, Masako
Komuro, Issei
Watanabe, Toshiaki
author_sort Nozawa, Hiroaki
collection PubMed
description Surgery is the mainstay of treatment for gastrointestinal stromal tumors (GISTs). However, complete resection of rectal GISTs is sometimes difficult because of bulkiness and/or anatomical reasons. Neoadjuvant imatinib therapy has gained attention as an alternative treatment to increase the chance of en bloc resection of rectal GISTs, although it usually takes several months. In this case report, we first demonstrated that neoadjuvant imatinib therapy can be performed safely not only to downsize tumors, but also to allow adequate time for the effective treatment of major comorbid illnesses. A 74-year-old man was diagnosed with a 45 mm GIST of the lower rectum. He also had severe stenosis in the proximal segment of the left anterior descending coronary artery. Following the implantation of a drug-eluting stent, the patient received imatinib together with dual anti-platelet therapy for 12 months without obvious side effects. Follow-up image studies revealed tumor shrinkage as well as stent patency. En bloc resection of the GIST was performed laparoscopically, which preserved the anus. The patient is currently alive without any evidence of relapse for 12 months after surgery.
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spelling pubmed-41075592014-07-24 Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy Nozawa, Hiroaki Kanazawa, Takamitsu Tanaka, Toshiaki Takahashi, Masao Ishihara, Soichiro Sunami, Eiji Kitayama, Joji Ikemura, Masako Komuro, Issei Watanabe, Toshiaki World J Surg Oncol Case Report Surgery is the mainstay of treatment for gastrointestinal stromal tumors (GISTs). However, complete resection of rectal GISTs is sometimes difficult because of bulkiness and/or anatomical reasons. Neoadjuvant imatinib therapy has gained attention as an alternative treatment to increase the chance of en bloc resection of rectal GISTs, although it usually takes several months. In this case report, we first demonstrated that neoadjuvant imatinib therapy can be performed safely not only to downsize tumors, but also to allow adequate time for the effective treatment of major comorbid illnesses. A 74-year-old man was diagnosed with a 45 mm GIST of the lower rectum. He also had severe stenosis in the proximal segment of the left anterior descending coronary artery. Following the implantation of a drug-eluting stent, the patient received imatinib together with dual anti-platelet therapy for 12 months without obvious side effects. Follow-up image studies revealed tumor shrinkage as well as stent patency. En bloc resection of the GIST was performed laparoscopically, which preserved the anus. The patient is currently alive without any evidence of relapse for 12 months after surgery. BioMed Central 2014-07-15 /pmc/articles/PMC4107559/ /pubmed/25022862 http://dx.doi.org/10.1186/1477-7819-12-211 Text en Copyright © 2014 Nozawa et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Nozawa, Hiroaki
Kanazawa, Takamitsu
Tanaka, Toshiaki
Takahashi, Masao
Ishihara, Soichiro
Sunami, Eiji
Kitayama, Joji
Ikemura, Masako
Komuro, Issei
Watanabe, Toshiaki
Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
title Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
title_full Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
title_fullStr Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
title_full_unstemmed Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
title_short Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
title_sort laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107559/
https://www.ncbi.nlm.nih.gov/pubmed/25022862
http://dx.doi.org/10.1186/1477-7819-12-211
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