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Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★

Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotecti...

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Autores principales: Tang, Hongmei, Pan, Rui, Fang, Wenli, Xing, Yanyan, Chen, Dexi, Chen, Xiaobao, Yu, Yuanyuan, Wang, Junbing, Gong, Zheng, Xiong, Guoyin, Dong, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107768/
https://www.ncbi.nlm.nih.gov/pubmed/25206431
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.15.003
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author Tang, Hongmei
Pan, Rui
Fang, Wenli
Xing, Yanyan
Chen, Dexi
Chen, Xiaobao
Yu, Yuanyuan
Wang, Junbing
Gong, Zheng
Xiong, Guoyin
Dong, Jun
author_facet Tang, Hongmei
Pan, Rui
Fang, Wenli
Xing, Yanyan
Chen, Dexi
Chen, Xiaobao
Yu, Yuanyuan
Wang, Junbing
Gong, Zheng
Xiong, Guoyin
Dong, Jun
author_sort Tang, Hongmei
collection PubMed
description Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca(2+) overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage.
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spelling pubmed-41077682014-09-09 Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★ Tang, Hongmei Pan, Rui Fang, Wenli Xing, Yanyan Chen, Dexi Chen, Xiaobao Yu, Yuanyuan Wang, Junbing Gong, Zheng Xiong, Guoyin Dong, Jun Neural Regen Res Research and Report Article: Traditional Chinese Medicine and Neural Regeneration Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca(2+) overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage. Medknow Publications & Media Pvt Ltd 2013-05-25 /pmc/articles/PMC4107768/ /pubmed/25206431 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.15.003 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
Tang, Hongmei
Pan, Rui
Fang, Wenli
Xing, Yanyan
Chen, Dexi
Chen, Xiaobao
Yu, Yuanyuan
Wang, Junbing
Gong, Zheng
Xiong, Guoyin
Dong, Jun
Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
title Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
title_full Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
title_fullStr Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
title_full_unstemmed Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
title_short Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
title_sort curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1★
topic Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107768/
https://www.ncbi.nlm.nih.gov/pubmed/25206431
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.15.003
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