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Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord
Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107770/ https://www.ncbi.nlm.nih.gov/pubmed/25206433 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.15.005 |
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author | Song, Changwei Fang, Shiqiang Lv, Gang Mei, Xifan |
author_facet | Song, Changwei Fang, Shiqiang Lv, Gang Mei, Xifan |
author_sort | Song, Changwei |
collection | PubMed |
description | Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury. |
format | Online Article Text |
id | pubmed-4107770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41077702014-09-09 Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord Song, Changwei Fang, Shiqiang Lv, Gang Mei, Xifan Neural Regen Res Research and Report Article: Traditional Chinese Medicine and Neural Regeneration Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury. Medknow Publications & Media Pvt Ltd 2013-05-25 /pmc/articles/PMC4107770/ /pubmed/25206433 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.15.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research and Report Article: Traditional Chinese Medicine and Neural Regeneration Song, Changwei Fang, Shiqiang Lv, Gang Mei, Xifan Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
title | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
title_full | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
title_fullStr | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
title_full_unstemmed | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
title_short | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
title_sort | gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord |
topic | Research and Report Article: Traditional Chinese Medicine and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107770/ https://www.ncbi.nlm.nih.gov/pubmed/25206433 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.15.005 |
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