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Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration

BACKGROUND: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease. OBJECTIVES: The Magnetic Imaging in MS (MAGNIMS) collaborative group sought to determine the relationship of brain lesion load, and brain and s...

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Autores principales: Kearney, H, Rocca, MA, Valsasina, P, Balk, L, Sastre-Garriga, J, Reinhardt, J, Ruggieri, S, Rovira, A, Stippich, C, Kappos, L, Sprenger, T, Tortorella, P, Rovaris, M, Gasperini, C, Montalban, X, Geurts, JJG, Polman, CH, Barkhof, F, Filippi, M, Altmann, DR, Ciccarelli, O, Miller, DH, Chard, DT
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107776/
https://www.ncbi.nlm.nih.gov/pubmed/23812283
http://dx.doi.org/10.1177/1352458513492245
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author Kearney, H
Rocca, MA
Valsasina, P
Balk, L
Sastre-Garriga, J
Reinhardt, J
Ruggieri, S
Rovira, A
Stippich, C
Kappos, L
Sprenger, T
Tortorella, P
Rovaris, M
Gasperini, C
Montalban, X
Geurts, JJG
Polman, CH
Barkhof, F
Filippi, M
Altmann, DR
Ciccarelli, O
Miller, DH
Chard, DT
author_facet Kearney, H
Rocca, MA
Valsasina, P
Balk, L
Sastre-Garriga, J
Reinhardt, J
Ruggieri, S
Rovira, A
Stippich, C
Kappos, L
Sprenger, T
Tortorella, P
Rovaris, M
Gasperini, C
Montalban, X
Geurts, JJG
Polman, CH
Barkhof, F
Filippi, M
Altmann, DR
Ciccarelli, O
Miller, DH
Chard, DT
author_sort Kearney, H
collection PubMed
description BACKGROUND: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease. OBJECTIVES: The Magnetic Imaging in MS (MAGNIMS) collaborative group sought to determine the relationship of brain lesion load, and brain and spinal cord atrophy, with physical disability in patients with long-established MS. METHODS: Patients had a magnetic resonance imaging (MRI) scan of their brain and spinal cord, from which we determined brain grey (GMF) and white matter (WMF) fractional volumes, upper cervical spinal cord cross-sectional area (UCCA) and brain T2-lesion volume (T2LV). We assessed patient disability using the Expanded Disability Status Scale (EDSS). We analysed associations between EDSS and MRI measures, using two regression models (dividing cohort by EDSS into two and four sub-groups). RESULTS: In the binary model, UCCA (p < 0.01) and T2LV (p = 0.02) were independently associated with the requirement of a walking aid. In the four-category model UCCA (p < 0.01), T2LV (p = 0.02) and GMF (p = 0.04) were independently associated with disability. CONCLUSIONS: Long-term physical disability was independently linked with atrophy of the spinal cord and brain T2 lesion load, and less consistently, with brain grey matter atrophy. Combinations of spinal cord and brain MRI measures may be required to capture clinically-relevant information in people with MS of long disease duration.
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spelling pubmed-41077762014-07-28 Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration Kearney, H Rocca, MA Valsasina, P Balk, L Sastre-Garriga, J Reinhardt, J Ruggieri, S Rovira, A Stippich, C Kappos, L Sprenger, T Tortorella, P Rovaris, M Gasperini, C Montalban, X Geurts, JJG Polman, CH Barkhof, F Filippi, M Altmann, DR Ciccarelli, O Miller, DH Chard, DT Mult Scler Research Papers BACKGROUND: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease. OBJECTIVES: The Magnetic Imaging in MS (MAGNIMS) collaborative group sought to determine the relationship of brain lesion load, and brain and spinal cord atrophy, with physical disability in patients with long-established MS. METHODS: Patients had a magnetic resonance imaging (MRI) scan of their brain and spinal cord, from which we determined brain grey (GMF) and white matter (WMF) fractional volumes, upper cervical spinal cord cross-sectional area (UCCA) and brain T2-lesion volume (T2LV). We assessed patient disability using the Expanded Disability Status Scale (EDSS). We analysed associations between EDSS and MRI measures, using two regression models (dividing cohort by EDSS into two and four sub-groups). RESULTS: In the binary model, UCCA (p < 0.01) and T2LV (p = 0.02) were independently associated with the requirement of a walking aid. In the four-category model UCCA (p < 0.01), T2LV (p = 0.02) and GMF (p = 0.04) were independently associated with disability. CONCLUSIONS: Long-term physical disability was independently linked with atrophy of the spinal cord and brain T2 lesion load, and less consistently, with brain grey matter atrophy. Combinations of spinal cord and brain MRI measures may be required to capture clinically-relevant information in people with MS of long disease duration. SAGE Publications 2014-01 /pmc/articles/PMC4107776/ /pubmed/23812283 http://dx.doi.org/10.1177/1352458513492245 Text en © The Author(s) 2013 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Research Papers
Kearney, H
Rocca, MA
Valsasina, P
Balk, L
Sastre-Garriga, J
Reinhardt, J
Ruggieri, S
Rovira, A
Stippich, C
Kappos, L
Sprenger, T
Tortorella, P
Rovaris, M
Gasperini, C
Montalban, X
Geurts, JJG
Polman, CH
Barkhof, F
Filippi, M
Altmann, DR
Ciccarelli, O
Miller, DH
Chard, DT
Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
title Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
title_full Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
title_fullStr Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
title_full_unstemmed Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
title_short Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
title_sort magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107776/
https://www.ncbi.nlm.nih.gov/pubmed/23812283
http://dx.doi.org/10.1177/1352458513492245
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