A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

The mechanisms by which tumor cells metastasize and the role of endocytic proteins in this process are not well understood. We report that overexpression of the GTPase RAB5A, a master regulator of endocytosis, is predictive of aggressive behavior and metastatic ability in human breast cancers. RAB5A...

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Detalles Bibliográficos
Autores principales: Frittoli, Emanuela, Palamidessi, Andrea, Marighetti, Paola, Confalonieri, Stefano, Bianchi, Fabrizio, Malinverno, Chiara, Mazzarol, Giovanni, Viale, Giuseppe, Martin-Padura, Ines, Garré, Massimilliano, Parazzoli, Dario, Mattei, Valentina, Cortellino, Salvatore, Bertalot, Giovanni, Di Fiore, Pier Paolo, Scita, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107781/
https://www.ncbi.nlm.nih.gov/pubmed/25049275
http://dx.doi.org/10.1083/jcb.201403127

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