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Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging
Traumatic spinal cord injury is often disabling and recovery of function is limited. As a consequence of damage, both spinal cord and brain undergo anatomical and functional changes. Besides clinical measures of recovery, biomarkers that can detect early anatomical and functional changes might be us...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107798/ https://www.ncbi.nlm.nih.gov/pubmed/22730072 http://dx.doi.org/10.1177/1073858412449192 |
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author | Freund, Patrick Curt, Armin Friston, Karl Thompson, Alan |
author_facet | Freund, Patrick Curt, Armin Friston, Karl Thompson, Alan |
author_sort | Freund, Patrick |
collection | PubMed |
description | Traumatic spinal cord injury is often disabling and recovery of function is limited. As a consequence of damage, both spinal cord and brain undergo anatomical and functional changes. Besides clinical measures of recovery, biomarkers that can detect early anatomical and functional changes might be useful in determining clinical outcome—during the course of rehabilitation and recovery—as well as furnishing a tool to evaluate novel treatment interventions and their mechanisms of action. Recent evidence suggests an interesting three-way relationship between neurological deficit and changes in the spinal cord and of the brain and that, importantly, noninvasive magnetic resonance imaging techniques, both structural and functional, provide a sensitive tool to lay out these interactions. This review describes recent findings from multimodal imaging studies of remote anatomical changes (i.e., beyond the lesion site), cortical reorganization, and their relationship to clinical disability. These developments in this field may improve our understanding of effects on the nervous system that are attributable to the injury itself and will allow their distinction from changes that result from rehabilitation (i.e., functional retraining) and from interventions affecting the nervous system directly (i.e., neuroprotection or regeneration). |
format | Online Article Text |
id | pubmed-4107798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-41077982014-07-28 Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging Freund, Patrick Curt, Armin Friston, Karl Thompson, Alan Neuroscientist Neuroscience in Translation Traumatic spinal cord injury is often disabling and recovery of function is limited. As a consequence of damage, both spinal cord and brain undergo anatomical and functional changes. Besides clinical measures of recovery, biomarkers that can detect early anatomical and functional changes might be useful in determining clinical outcome—during the course of rehabilitation and recovery—as well as furnishing a tool to evaluate novel treatment interventions and their mechanisms of action. Recent evidence suggests an interesting three-way relationship between neurological deficit and changes in the spinal cord and of the brain and that, importantly, noninvasive magnetic resonance imaging techniques, both structural and functional, provide a sensitive tool to lay out these interactions. This review describes recent findings from multimodal imaging studies of remote anatomical changes (i.e., beyond the lesion site), cortical reorganization, and their relationship to clinical disability. These developments in this field may improve our understanding of effects on the nervous system that are attributable to the injury itself and will allow their distinction from changes that result from rehabilitation (i.e., functional retraining) and from interventions affecting the nervous system directly (i.e., neuroprotection or regeneration). SAGE Publications 2013-04 /pmc/articles/PMC4107798/ /pubmed/22730072 http://dx.doi.org/10.1177/1073858412449192 Text en © The Author(s) 2012 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Neuroscience in Translation Freund, Patrick Curt, Armin Friston, Karl Thompson, Alan Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging |
title | Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging |
title_full | Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging |
title_fullStr | Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging |
title_full_unstemmed | Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging |
title_short | Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging |
title_sort | tracking changes following spinal cord injury: insights from neuroimaging |
topic | Neuroscience in Translation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107798/ https://www.ncbi.nlm.nih.gov/pubmed/22730072 http://dx.doi.org/10.1177/1073858412449192 |
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