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How does the motor relearning program improve neurological function of brain ischemia monkeys?☆

The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the...

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Autores principales: Yin, Yong, Gu, Zhen, Pan, Lei, Gan, Lu, Qin, Dongdong, Yang, Bo, Guo, Jin, Hu, Xintian, Wang, Tinghua, Feng, Zhongtang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107808/
https://www.ncbi.nlm.nih.gov/pubmed/25206440
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.16.001
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author Yin, Yong
Gu, Zhen
Pan, Lei
Gan, Lu
Qin, Dongdong
Yang, Bo
Guo, Jin
Hu, Xintian
Wang, Tinghua
Feng, Zhongtang
author_facet Yin, Yong
Gu, Zhen
Pan, Lei
Gan, Lu
Qin, Dongdong
Yang, Bo
Guo, Jin
Hu, Xintian
Wang, Tinghua
Feng, Zhongtang
author_sort Yin, Yong
collection PubMed
description The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia.
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spelling pubmed-41078082014-09-09 How does the motor relearning program improve neurological function of brain ischemia monkeys?☆ Yin, Yong Gu, Zhen Pan, Lei Gan, Lu Qin, Dongdong Yang, Bo Guo, Jin Hu, Xintian Wang, Tinghua Feng, Zhongtang Neural Regen Res Neurorehabilitation and Neural Regeneration The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. Medknow Publications & Media Pvt Ltd 2013-06-05 /pmc/articles/PMC4107808/ /pubmed/25206440 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.16.001 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neurorehabilitation and Neural Regeneration
Yin, Yong
Gu, Zhen
Pan, Lei
Gan, Lu
Qin, Dongdong
Yang, Bo
Guo, Jin
Hu, Xintian
Wang, Tinghua
Feng, Zhongtang
How does the motor relearning program improve neurological function of brain ischemia monkeys?☆
title How does the motor relearning program improve neurological function of brain ischemia monkeys?☆
title_full How does the motor relearning program improve neurological function of brain ischemia monkeys?☆
title_fullStr How does the motor relearning program improve neurological function of brain ischemia monkeys?☆
title_full_unstemmed How does the motor relearning program improve neurological function of brain ischemia monkeys?☆
title_short How does the motor relearning program improve neurological function of brain ischemia monkeys?☆
title_sort how does the motor relearning program improve neurological function of brain ischemia monkeys?☆
topic Neurorehabilitation and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107808/
https://www.ncbi.nlm.nih.gov/pubmed/25206440
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.16.001
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