Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report

Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML...

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Autores principales: Trosclair, Christopher, Pollen, Maressa, Capraro, Gerald, Cotelingam, James, Shackelford, Rodney E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Published online: June, 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107820/
https://www.ncbi.nlm.nih.gov/pubmed/25076892
http://dx.doi.org/10.1159/000365002
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author Trosclair, Christopher
Pollen, Maressa
Capraro, Gerald
Cotelingam, James
Shackelford, Rodney E.
author_facet Trosclair, Christopher
Pollen, Maressa
Capraro, Gerald
Cotelingam, James
Shackelford, Rodney E.
author_sort Trosclair, Christopher
collection PubMed
description Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.
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spelling pubmed-41078202014-07-30 Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report Trosclair, Christopher Pollen, Maressa Capraro, Gerald Cotelingam, James Shackelford, Rodney E. Case Rep Oncol Published online: June, 2014 Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype. S. Karger AG 2014-06-25 /pmc/articles/PMC4107820/ /pubmed/25076892 http://dx.doi.org/10.1159/000365002 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: June, 2014
Trosclair, Christopher
Pollen, Maressa
Capraro, Gerald
Cotelingam, James
Shackelford, Rodney E.
Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
title Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
title_full Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
title_fullStr Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
title_full_unstemmed Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
title_short Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
title_sort acute myelogenous leukemia without maturation with a retinoic alpha-receptor deletion: a case report
topic Published online: June, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107820/
https://www.ncbi.nlm.nih.gov/pubmed/25076892
http://dx.doi.org/10.1159/000365002
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