Cargando…

Structure and function study of the complex that synthesizes S-adenosylmethionine

S-Adenosylmethionine (SAMe) is the principal methyl donor of the cell and is synthesized via an ATP-driven process by methionine adenosyltransferase (MAT) enzymes. It is tightly linked with cell proliferation in liver and colon cancer. In humans, there are three genes, mat1A, mat2A and mat2B, which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murray, Ben, Antonyuk, Svetlana V., Marina, Alberto, Van Liempd, Sebastiaan M., Lu, Shelly C., Mato, Jose M., Hasnain, S. Samar, Rojas, Adriana L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107924/ https://www.ncbi.nlm.nih.gov/pubmed/25075345 http://dx.doi.org/10.1107/S2052252514012585

Ejemplares similares

Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds
por: Panmanee, Jiraporn, et al.
Publicado: (2019)

Structures of Protein-Protein Complexes involved in electron transfer
por: Antonyuk, Svetlana V., et al.
Publicado: (2013)

Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene
por: Panmanee, Jiraporn, et al.
Publicado: (2020)

The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM
por: Muench, Stephen P., et al.
Publicado: (2019)

One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes
por: Fernández-Ramos, David, et al.
Publicado: (2022)

Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase
por: Strange, Richard W., et al.
Publicado: (2012)

Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency
por: Robinson, Aaron E., et al.
Publicado: (2023)

Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes
por: Sasaki, Daisuke, et al.
Publicado: (2020)

Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential
por: Blakeley, Matthew P., et al.
Publicado: (2015)

A faulty interaction between SOD1 and hCCS in neurodegenerative disease
por: Wright, Gareth S. A., et al.
Publicado: (2016)

A 2.2 Å cryoEM structure of a quinol-dependent NO Reductase shows close similarity to respiratory oxidases
por: Flynn, Alex J., et al.
Publicado: (2023)

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc (1) complexes for structure-based drug discovery
por: Amporndanai, Kangsa, et al.
Publicado: (2018)

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM
por: Chiduza, George N., et al.
Publicado: (2019)

Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426
por: Padmanabhan, Balasundaram, et al.
Publicado: (2013)

The Biochemistry of Adenosylmethionine
por: Kraus, Jan
Publicado: (1978)

Identification of a tyrosine switch in copper-haem nitrite reductases
por: Dong, Jianshu, et al.
Publicado: (2018)

Radical S-Adenosylmethionine Enzymes
por: Broderick, Joan B., et al.
Publicado: (2014)

Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
por: Capelo-Diz, Alba, et al.
Publicado: (2023)

Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase
por: Bale, Shridhar, et al.
Publicado: (2008)

Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases
por: Wright, Gareth S.A., et al.
Publicado: (2020)

Ligand binding and aggregation of pathogenic SOD1
por: Wright, Gareth S.A., et al.
Publicado: (2013)

Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS
por: Sala, Fernanda A., et al.
Publicado: (2019)

New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C(8) Substitution in Structural Analogues of S-Adenosylmethionine
por: McCloskey, Diane E., et al.
Publicado: (2009)

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol
por: Dickens, David, et al.
Publicado: (2017)

Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy
por: Gopalasingam, Chai C., et al.
Publicado: (2019)

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle
por: Ruan, Liying, et al.
Publicado: (2019)

Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal
por: Horrell, Sam, et al.
Publicado: (2016)

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase
por: Leferink, Nicole G. H., et al.
Publicado: (2014)

Natural history of S-adenosylmethionine-binding proteins
por: Kozbial, Piotr Z, et al.
Publicado: (2005)

Potential role of S-adenosylmethionine in osteosarcoma development
por: Shi, Hui, et al.
Publicado: (2016)

How a Subfamily of Radical S-Adenosylmethionine Enzymes Became a Mainstay of Ribosomally Synthesized and Post-translationally Modified Peptide Discovery
por: Mendauletova, Aigera, et al.
Publicado: (2021)

Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis
por: Hough, Michael A., et al.
Publicado: (2020)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures
por: Rose, Samuel L., et al.
Publicado: (2021)

Expression of S-adenosylmethionine Hydrolase in Tissues Synthesizing Secondary Cell Walls Alters Specific Methylated Cell Wall Fractions and Improves Biomass Digestibility
por: Eudes, Aymerick, et al.
Publicado: (2016)

Engineered Pichia pastoris for enhanced production of S-adenosylmethionine
por: Kamarthapu, Venu, et al.
Publicado: (2013)

S‐adenosylmethionine: A metabolite critical to the regulation of autophagy
por: Ouyang, Yang, et al.
Publicado: (2020)

Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine
por: Sun, Yudong, et al.
Publicado: (2021)

Coupling S-adenosylmethionine–dependent methylation to growth: Design and uses
por: Luo, Hao, et al.
Publicado: (2019)

The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer
por: Jamali, M. Arif M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c3i94cftjca1boh5cp5elannoa