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Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia

ABSTRACT: BACKGROUND: This study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person. METHODS: A retrospective study of sixty BPH patients (aged 73.5 ±...

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Autores principales: Shi, Jingfang, Yin, Xiaohua, Xu, Rong, Wang, Yingchun, Jin, Lin, Gao, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108000/
https://www.ncbi.nlm.nih.gov/pubmed/24986664
http://dx.doi.org/10.1186/1746-1596-9-133
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author Shi, Jingfang
Yin, Xiaohua
Xu, Rong
Wang, Yingchun
Jin, Lin
Gao, Weiwei
author_facet Shi, Jingfang
Yin, Xiaohua
Xu, Rong
Wang, Yingchun
Jin, Lin
Gao, Weiwei
author_sort Shi, Jingfang
collection PubMed
description ABSTRACT: BACKGROUND: This study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person. METHODS: A retrospective study of sixty BPH patients (aged 73.5 ± 20.5 years old) and thirty normal controls without prostate diseases (aged 75.3 ± 19.7 years old) who had accepted CEUS detection were performed. Time-intensity curves were obtained for all tests in regions of interest. Images were processed using ACQ software and the following parameters were obtained: arrival time (AT), peak intensity (P), time to peak (TP), area under the curve (AUC), mean transit time (MTT) and extinction time (ET). Differences in inner and outer gland of prostate between BPH and the normal tissue were evaluated. RESULTS: There was a clear boundary between the inner and outer gland of BPH prostate. AT, TP, MTT, ET and P in BPH outer gland were significantly higher than the control group. In inner gland, MTT, ET, AUC and P were also significantly higher than the controls. The accurate rate to diagnose BPH using CEUS was 95.6%, and the sensitivity and specificity were 95.0% and 96.7%, respectively. CONCLUSIONS: Among these significantly changed parameters, the increases of MTT, ET and AUC in inner gland and AT, TP in outer gland were most likely related to BPH. These parameters provide an objective visual assessment to diagnosis of BPH. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4852383312229155
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spelling pubmed-41080002014-07-24 Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia Shi, Jingfang Yin, Xiaohua Xu, Rong Wang, Yingchun Jin, Lin Gao, Weiwei Diagn Pathol Research ABSTRACT: BACKGROUND: This study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person. METHODS: A retrospective study of sixty BPH patients (aged 73.5 ± 20.5 years old) and thirty normal controls without prostate diseases (aged 75.3 ± 19.7 years old) who had accepted CEUS detection were performed. Time-intensity curves were obtained for all tests in regions of interest. Images were processed using ACQ software and the following parameters were obtained: arrival time (AT), peak intensity (P), time to peak (TP), area under the curve (AUC), mean transit time (MTT) and extinction time (ET). Differences in inner and outer gland of prostate between BPH and the normal tissue were evaluated. RESULTS: There was a clear boundary between the inner and outer gland of BPH prostate. AT, TP, MTT, ET and P in BPH outer gland were significantly higher than the control group. In inner gland, MTT, ET, AUC and P were also significantly higher than the controls. The accurate rate to diagnose BPH using CEUS was 95.6%, and the sensitivity and specificity were 95.0% and 96.7%, respectively. CONCLUSIONS: Among these significantly changed parameters, the increases of MTT, ET and AUC in inner gland and AT, TP in outer gland were most likely related to BPH. These parameters provide an objective visual assessment to diagnosis of BPH. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4852383312229155 BioMed Central 2014-07-01 /pmc/articles/PMC4108000/ /pubmed/24986664 http://dx.doi.org/10.1186/1746-1596-9-133 Text en Copyright © 2014 Shi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shi, Jingfang
Yin, Xiaohua
Xu, Rong
Wang, Yingchun
Jin, Lin
Gao, Weiwei
Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
title Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
title_full Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
title_fullStr Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
title_full_unstemmed Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
title_short Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
title_sort clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108000/
https://www.ncbi.nlm.nih.gov/pubmed/24986664
http://dx.doi.org/10.1186/1746-1596-9-133
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