Cargando…

Nanotechnology in drug delivery: the need for more cell culture based studies in screening

Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability. Humans are the target of these systems, hence, animals whose systems resembles humans were used to pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kura, Aminu Umar, Fakurazi, Sharida, Hussein, Mohd Zobir, Arulselvan, Palanisamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108003/
https://www.ncbi.nlm.nih.gov/pubmed/25057288
http://dx.doi.org/10.1186/1752-153X-8-46
_version_ 1782327690786766848
author Kura, Aminu Umar
Fakurazi, Sharida
Hussein, Mohd Zobir
Arulselvan, Palanisamy
author_facet Kura, Aminu Umar
Fakurazi, Sharida
Hussein, Mohd Zobir
Arulselvan, Palanisamy
author_sort Kura, Aminu Umar
collection PubMed
description Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability. Humans are the target of these systems, hence, animals whose systems resembles humans were used to predict outcome. Thus, increasing costs in money and time, plus ethical concerns over animal usage. However, with consideration and planning in experimental conditions, in vitro pharmacological studies of the nanodelivery can mimic the in vivo system. This can function as a simple method to investigate the effect of such materials without endangering animals especially at screening phase.
format Online
Article
Text
id pubmed-4108003
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-41080032014-07-24 Nanotechnology in drug delivery: the need for more cell culture based studies in screening Kura, Aminu Umar Fakurazi, Sharida Hussein, Mohd Zobir Arulselvan, Palanisamy Chem Cent J Mini Review Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability. Humans are the target of these systems, hence, animals whose systems resembles humans were used to predict outcome. Thus, increasing costs in money and time, plus ethical concerns over animal usage. However, with consideration and planning in experimental conditions, in vitro pharmacological studies of the nanodelivery can mimic the in vivo system. This can function as a simple method to investigate the effect of such materials without endangering animals especially at screening phase. BioMed Central 2014-07-16 /pmc/articles/PMC4108003/ /pubmed/25057288 http://dx.doi.org/10.1186/1752-153X-8-46 Text en Copyright © 2014 Kura et al.; licensee Chemistry Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Mini Review
Kura, Aminu Umar
Fakurazi, Sharida
Hussein, Mohd Zobir
Arulselvan, Palanisamy
Nanotechnology in drug delivery: the need for more cell culture based studies in screening
title Nanotechnology in drug delivery: the need for more cell culture based studies in screening
title_full Nanotechnology in drug delivery: the need for more cell culture based studies in screening
title_fullStr Nanotechnology in drug delivery: the need for more cell culture based studies in screening
title_full_unstemmed Nanotechnology in drug delivery: the need for more cell culture based studies in screening
title_short Nanotechnology in drug delivery: the need for more cell culture based studies in screening
title_sort nanotechnology in drug delivery: the need for more cell culture based studies in screening
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108003/
https://www.ncbi.nlm.nih.gov/pubmed/25057288
http://dx.doi.org/10.1186/1752-153X-8-46
work_keys_str_mv AT kuraaminuumar nanotechnologyindrugdeliverytheneedformorecellculturebasedstudiesinscreening
AT fakurazisharida nanotechnologyindrugdeliverytheneedformorecellculturebasedstudiesinscreening
AT husseinmohdzobir nanotechnologyindrugdeliverytheneedformorecellculturebasedstudiesinscreening
AT arulselvanpalanisamy nanotechnologyindrugdeliverytheneedformorecellculturebasedstudiesinscreening