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Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease
Alzheimer’s disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic pote...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108086/ https://www.ncbi.nlm.nih.gov/pubmed/24597505 http://dx.doi.org/10.2174/1567205011666140302200312 |
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author | Zhang, Ningnannan Song, Xiaowei Bartha, Robert Beyea, Steven D’Arcy, Ryan Zhang, Yunting Rockwood, Kenneth |
author_facet | Zhang, Ningnannan Song, Xiaowei Bartha, Robert Beyea, Steven D’Arcy, Ryan Zhang, Yunting Rockwood, Kenneth |
author_sort | Zhang, Ningnannan |
collection | PubMed |
description | Alzheimer’s disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent use of high magnetic fields has led to significantly improved signal-to-noise ratios and spectral resolutions, thereby allowing clinical applications with increased measurement reliability. The present article provides a comprehensive review of SV 1H MRS studies on AD at high magnetic fields (3.0 Tesla and above). This review suggests that patterned regional differences and longitudinal alterations in several neurometabolites are associated with clinically established AD. Changes in multiple metabolites are identifiable even at early stages of AD development. By combining information of neurochemicals in different brain regions revealing either pathological or compensatory changes, high field MRS can be evaluated in AD diagnosis and in the detection of treatment effects. To achieve this, standardization of data acquisition and analytical approaches is needed. |
format | Online Article Text |
id | pubmed-4108086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-41080862014-07-24 Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease Zhang, Ningnannan Song, Xiaowei Bartha, Robert Beyea, Steven D’Arcy, Ryan Zhang, Yunting Rockwood, Kenneth Curr Alzheimer Res Article Alzheimer’s disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent use of high magnetic fields has led to significantly improved signal-to-noise ratios and spectral resolutions, thereby allowing clinical applications with increased measurement reliability. The present article provides a comprehensive review of SV 1H MRS studies on AD at high magnetic fields (3.0 Tesla and above). This review suggests that patterned regional differences and longitudinal alterations in several neurometabolites are associated with clinically established AD. Changes in multiple metabolites are identifiable even at early stages of AD development. By combining information of neurochemicals in different brain regions revealing either pathological or compensatory changes, high field MRS can be evaluated in AD diagnosis and in the detection of treatment effects. To achieve this, standardization of data acquisition and analytical approaches is needed. Bentham Science Publishers 2014-05 2014-05 /pmc/articles/PMC4108086/ /pubmed/24597505 http://dx.doi.org/10.2174/1567205011666140302200312 Text en © 2014 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Zhang, Ningnannan Song, Xiaowei Bartha, Robert Beyea, Steven D’Arcy, Ryan Zhang, Yunting Rockwood, Kenneth Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease |
title | Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease |
title_full | Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease |
title_fullStr | Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease |
title_full_unstemmed | Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease |
title_short | Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease |
title_sort | advances in high-field magnetic resonance spectroscopy in alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108086/ https://www.ncbi.nlm.nih.gov/pubmed/24597505 http://dx.doi.org/10.2174/1567205011666140302200312 |
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