Cargando…

Neuroinflammation and related neuropathologies in APP(SL) mice: further value of this in vivo model of Alzheimer’s disease

BACKGROUND: Beyond cognitive decline, Alzheimer’s disease (AD) is characterized by numerous neuropathological changes in the brain. Although animal models generally do not fully reflect the broad spectrum of disease-specific alterations, the APP(SL) mouse model is well known to display early plaque...

Descripción completa

Detalles Bibliográficos
Autores principales:	Löffler, Tina, Flunkert, Stefanie, Havas, Daniel, Schweinzer, Cornelia, Uger, Marni, Windisch, Manfred, Steyrer, Ernst, Hutter-Paier, Birgit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108132/ https://www.ncbi.nlm.nih.gov/pubmed/24886182 http://dx.doi.org/10.1186/1742-2094-11-84

Ejemplares similares

Decreased Plasma Aβ in Hyperlipidemic APP(SL) Transgenic Mice Is Associated with BBB Dysfunction
por: Löffler, Tina, et al.
Publicado: (2016)

Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates
por: Löffler, Tina, et al.
Publicado: (2012)

Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease
por: Hinteregger, Barbara, et al.
Publicado: (2021)

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model
por: Amschl, David, et al.
Publicado: (2013)

Development of GMP‐1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease
por: Pavlov, Pavel F., et al.
Publicado: (2018)

Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
por: Molnar-Kasza, Agnes, et al.
Publicado: (2021)

Non-Selective Calcium Channel Blocker Bepridil Decreases Secondary Pathology in Mice after Photothrombotic Cortical Lesion
por: Lipsanen, Anu, et al.
Publicado: (2013)

Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value
por: Loeffler, Tina, et al.
Publicado: (2020)

mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms
por: Scherz, Barbara, et al.
Publicado: (2018)

Editorial: Neuronopathic lysosomal storage diseases - specific neuronal characteristics and therapeutic approaches
por: Flunkert, Stefanie, et al.
Publicado: (2022)

Comparison of Pharmacological Modulation of APP Metabolism in Primary Chicken Telencephalic Neurons and in a Human Neuroglioma Cell Line
por: Czvitkovich, Stefan, et al.
Publicado: (2010)

Hepatic and neuronal phenotype of NPC1(−/−) mice
por: Santiago-Mujica, Estibaliz, et al.
Publicado: (2019)

Constant Levels of Tau Phosphorylation in the Brain of htau Mice
por: Neddens, Joerg, et al.
Publicado: (2020)

Neuroinflammation and Neuropathology
por: Esin, R. G., et al.
Publicado: (2022)

Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
por: Filip, Thomas, et al.
Publicado: (2021)

Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer’s disease and related murine models
por: Neddens, Joerg, et al.
Publicado: (2020)

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
por: Causevic, Mirsada, et al.
Publicado: (2018)

Transgene integration causes RARB downregulation in homozygous Tg4–42 mice
por: Hinteregger, Barbara, et al.
Publicado: (2020)

Leukotriene Signaling as a Target in α-Synucleinopathies
por: Strempfl, Katharina, et al.
Publicado: (2022)

Phosphorylation of different tau sites during progression of Alzheimer’s disease
por: Neddens, Joerg, et al.
Publicado: (2018)

L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model
por: Daschil, Nina, et al.
Publicado: (2015)

Quantification of Huntington’s Disease Related Markers in the R6/2 Mouse Model
por: Etxeberria-Rekalde, Estibaliz, et al.
Publicado: (2021)

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models
por: Sharghi, Shirin, et al.
Publicado: (2023)

Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease
por: Schiffer, Victoria, et al.
Publicado: (2020)

DIABRISK-SL trial: further consideration of age and impact of imputations
por: Gkioni, Efstathia, et al.
Publicado: (2019)

The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
por: Michael, Johanna, et al.
Publicado: (2021)

Spatial Distribution of Neuropathology and Neuroinflammation Elucidate the Biomechanics of Fluid Percussion Injury
por: Beitchman, Joshua A., et al.
Publicado: (2021)

Potential Role of Intracranial Mast Cells in Neuroinflammation and Neuropathology Associated with Food Allergy
por: Germundson, Danielle L., et al.
Publicado: (2022)

Synaptojanin 1 Mutation in Parkinson's Disease Brings Further Insight into the Neuropathological Mechanisms
por: Drouet, Valérie, et al.
Publicado: (2014)

Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice
por: Rabl, R., et al.
Publicado: (2017)

Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation
por: Dayton, Jacquelyn R., et al.
Publicado: (2021)

Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology
por: Houser, Madelyn C., et al.
Publicado: (2021)

Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APP(SL) and APP(SL)/PS1(M146L) Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?
por: Barrier, Laurence, et al.
Publicado: (2010)

Development and Characterization of a Camelid Single Domain Antibody–Urease Conjugate That Targets Vascular Endothelial Growth Factor Receptor 2
por: Tian, Baomin, et al.
Publicado: (2017)

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice
por: Fiorentini, Anna, et al.
Publicado: (2010)

The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
por: Zuliani, Ilaria, et al.
Publicado: (2020)

Vaccine Development to Treat Alzheimer's Disease Neuropathology in APP/PS1 Transgenic Mice
por: Carrera, Iván, et al.
Publicado: (2012)

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
por: Yang, Wenjuan, et al.
Publicado: (2018)

Semileptonic asymmetries: a$^{d} _{sl}$ and a$^{s} _{sl}$
por: Wimberley, Jack
Publicado: (2016)

AIDS-Myelopathy: A Neuropathological Study
por: Bergmann, M., et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_3jfpq0nal1tljroa43dqors2b7